从亚洲类叶升麻中分离得到的六种新环阿尔廷烷型三萜糖苷。

Six new cycloartane triterpene glycosides from Actaea asiatica.

作者信息

Fan Yun-Shuang, Yao Zhi, Zhang Yan-Wen, Duan Hong-Quan

机构信息

Key Laboratory of Hollow Fiber Membrane Material and Membrane Process of Ministry of Education, Tianjin Polytechnic University, Tianjin, China.

出版信息

J Asian Nat Prod Res. 2009 Jul;11(7):588-96. doi: 10.1080/10286020902819848.

DOI:10.1080/10286020902819848

PMID:20183295

Abstract

Six new cycloartane triterpene glycosides, (3',12beta)-O-diacetyl-cimigenol-3-O-beta-D-xylopyranoside (1), (4',25)-O-diacetyl-cimigenol-3-O-beta-D-xylopyranoside (2), 2'-O-acetyl-25-O-methyl-cimigenol-3-O-beta-D-xylopyranoside (3), 2'-O-acetyl-25-O-ethyl-cimigenol-3-O-beta-D-xylopyranoside (4), 3'-O-acetyl-cimicifugoside (5), and 4'-O-acetyl-23-epi-26-deoxycimifugoside (6), were isolated from the rhizomes of Actaea asiatica. Their structures were elucidated on the basis of chemical methods and spectroscopic analysis. Compounds 1, 2, 4-6 exhibited positive cytotoxic activities.

摘要

从亚洲类叶升麻的根茎中分离出六种新的环阿尔廷烷三萜糖苷，即(3',12β)-O-二乙酰升麻醇-3-O-β-D-吡喃木糖苷(1)、(4',25)-O-二乙酰升麻醇-3-O-β-D-吡喃木糖苷(2)、2'-O-乙酰基-25-O-甲基升麻醇-3-O-β-D-吡喃木糖苷(3)、2'-O-乙酰基-25-O-乙基升麻醇-3-O-β-D-吡喃木糖苷(4)、3'-O-乙酰基升麻苷(5)和4'-O-乙酰基-23-表-26-脱氧升麻苷(6)。通过化学方法和光谱分析对它们的结构进行了阐明。化合物1、2、4 - 6表现出阳性细胞毒性活性。