梭罗皂苷O，一种从阴道毛茛中分离得到的新型环羊毛甾烷型三萜糖苷。

Soulieoside O, a new cyclolanostane triterpenoid glycoside from Souliea vaginata.

作者信息

Wu Hai-Feng, Li Peng-Fei, Zhu Yin-Di, Zhang Xiao-Po, Ma Guo-Xu, Xu Xu-Dong, Liu Yi-Lin, Luo Zheng-Hong, Chen Di-Zhao, Zou Qiong-Yu, Zhao Zi-Jian

机构信息

a Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100193 , China.

b School of Pharmacy, Wenzhou Medical University , Wenzhou 325035 , China.

出版信息

J Asian Nat Prod Res. 2017 Dec;19(12):1177-1182. doi: 10.1080/10286020.2017.1307190. Epub 2017 Apr 4.

DOI:10.1080/10286020.2017.1307190

PMID:28374633

Abstract

A new cyclolanostane triterpenoid glycoside, soulieoside O (1), together with 25-O-acetylcimigenol-3-O-β-d-xylopyranoside (2) and cimigenol-3-O-β-d-xylopyranoside (3), was isolated from the rhizomes of Souliea vaginata. Their structures were characterized by spectroscopic analysis and chemical methods. The new compound showed moderate inhibitory activity against three human cancer cell lines with IC values of 9.3-22.5 μM.

摘要

从阴道毛茛的根茎中分离出一种新的环羊毛甾烷三萜糖苷，索里皂苷O（1），以及25 - O - 乙酰升麻醇 - 3 - O - β - D - 木糖苷（2）和升麻醇 - 3 - O - β - D - 木糖苷（3）。通过光谱分析和化学方法对它们的结构进行了表征。该新化合物对三种人类癌细胞系显示出中等抑制活性，IC值为9.3 - 22.5 μM。