State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China.
J Nat Prod. 2010 Feb 26;73(2):93-8. doi: 10.1021/np9003855.
Seven new 9,19-cycloartane triterpene glycosides, 25-O-acetylcimigenol-3-O-[2'-O-(E)-2-butenoyl]-beta-d-xylopyranoside (1), 25-O-acetylcimigenol-3-O-[4'-O-(E)-2-butenoyl]-beta-d-xylopyranoside (2), 25-O-acetylcimigenol-3-O-[3'-O-acetyl]-beta-d-xylopyranoside (3), 25-O-acetylcimigenol-3-O-[4'-O-acetyl]-beta-d-xylopyranoside (4), 25-O-acetyl-12beta-acetoxycimigenol-3-O-beta-d-xylopyranoside (5), 3'-O-acetylactein (6), and 3'-O-acetyl-23-epi-26-deoxyactein (7), together with eight known compounds (8-15), were isolated from the roots of Cimicifuga fetida. Their structures were established by spectroscopic and chemical methods. Most of these compounds showed more selective and higher cytotoxicity against the human HepG2 cell line than against the MCF7, HT29, and MKN28 cell lines. Compounds 2, 3, and 7 exhibited significant cytotoxicity against HepG2 cells, with IC(50) values of 1.29, 0.71, and 1.41 microM, respectively.
从升麻根中分离得到了七种新的 9,19-环阿尔廷三萜糖苷，25-O-乙酰齐墩果酸-3-O-[2'-O-(E)-2-丁烯酰基]-β-D-木吡喃糖苷（1）、25-O-乙酰齐墩果酸-3-O-[4'-O-(E)-2-丁烯酰基]-β-D-木吡喃糖苷（2）、25-O-乙酰齐墩果酸-3-O-[3'-O-乙酰基]-β-D-木吡喃糖苷（3）、25-O-乙酰齐墩果酸-3-O-[4'-O-乙酰基]-β-D-木吡喃糖苷（4）、25-O-乙酰基-12β-乙酰氧基齐墩果酸-3-O-β-D-木吡喃糖苷（5）、3'-O-乙酰基升麻醇（6）和 3'-O-乙酰基-23-表-26-去氧升麻醇（7），以及八种已知化合物（8-15）。这些化合物的结构通过光谱和化学方法确定。这些化合物大多数对人 HepG2 细胞系具有更高的选择性和更强的细胞毒性，而对 MCF7、HT29 和 MKN28 细胞系的毒性较低。化合物 2、3 和 7 对 HepG2 细胞表现出显著的细胞毒性，IC50 值分别为 1.29、0.71 和 1.41 μM。
