Sesquiterpenes from Curcuma wenyujin with their inhibitory activities on nitric oxide production in RAW 264.7 cells.
作者信息
Gao Suyu, Xia Guiyang, Wang Liqing, Zhou Li, Zhao Feng, Huang Jian, Chen Lixia
机构信息
a Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Department of Natural Products Chemistry , School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University , Shenyang , People's Republic of China.
b Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, School of Pharmacy , Yantai University , Yantai , People's Republic of China.
出版信息
Nat Prod Res. 2017 Mar;31(5):548-554. doi: 10.1080/14786419.2016.1205053. Epub 2016 Jul 19.
One new sesquiterpene, 7α,11-epoxy-6α-hydroxy-carabrane-4,8-dione, along with 10 known ones were isolated from the essential oil of Curcuma wenyujin Y.H. Chen et C. Ling. Their structures were established based on extensive spectroscopic analysis. The absolute configuration of compound 1 was determined by the CD analysis of the insitu formed [Rh(OCOCF)] complex, and the CD data analysis based on the octane rule of cyclohexanone. The inhibitory effects of these sesquiterpenes on nitric oxide production in lipopolysaccharide-activated macrophages were also evaluated. Furthermore, the biosynthesis pathway of the isolated compounds was proposed.
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