Tai Bui Huu, Cuong Nguyen Manh, Huong Tran Thu, Choi Eun-Mi, Kim Jeong-Ah, Kim Young Ho
Chungnam National University, Daejeon, South Korea.
J Asian Nat Prod Res. 2009 Sep;11(9):817-23. doi: 10.1080/10286020903117317.
Chrysoeriol (1) was isolated as the main constituent from the methanol extract of the dried leaves of Eurya ciliata Merr. To investigate the bioactivities of 1 on bone metabolism, its effects on the function of osteoblastic MC3T3-E1 cells were studied. Compound 1 significantly increased the growth of MC3T3-E1 cells and caused a significant elevation of alkaline phosphatase activity, collagen content, and nodule mineralization in the cells (P < 0.05). Our data indicate that the enhancement of osteoblast function by 1 may be useful in the prevention of osteoporosis.
金腰箭素（1）是从毛叶柃干燥叶片的甲醇提取物中分离得到的主要成分。为了研究1对骨代谢的生物活性，研究了其对成骨细胞MC3T3-E1细胞功能的影响。化合物1显著促进了MC3T3-E1细胞的生长，并使细胞中的碱性磷酸酶活性、胶原蛋白含量和结节矿化显著升高（P < 0.05）。我们的数据表明，1对成骨细胞功能的增强作用可能有助于预防骨质疏松症。
