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对 Nakai 变型地上部分的植物化学研究及其生物活性。

Phytochemical investigation on the aerial parts of f. Nakai and their biological activities.

作者信息

Hong Seong Su, Lee Jae Yeon, Jeong Yeon Woo, Lee Ji Eun, Choi Yun-Hyeok, Jeong Wonsik, Ahn Eun-Kyung, Choi Chun Whan, Ahn Il Ho, Oh Joa Sub

机构信息

Bio-Center, Gyeonggido Business & Science Accelerator (GBSA), Suwon, Republic of Korea.

NewCellPharm Co., Ltd., Seongnam, Republic of Korea.

出版信息

Turk J Chem. 2023 Sep 12;47(6):1346-1354. doi: 10.55730/1300-0527.3618. eCollection 2023.

DOI:10.55730/1300-0527.3618
PMID:38544705
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10965189/
Abstract

spp. have traditionally been used in folk medicine to treat various pathologies. In this study, nine compounds, comprising one simple phenolic compound (), three stilbenoids (-), and five flavonoids (-), were isolated from the aerial parts of f. Nakai. The structures of these compounds were elucidated by spectroscopic analyses and comparison with reported data. Together, all reported compounds were isolated from f. for the first time in the study. Among them, two flavone aglycone tricetins ( and ) have never been isolated from the genus or the family Melanthiaceae. The ethanol extract and isolated compounds were assessed for their inhibitory effects on elastase, tyrosinase, and melanin synthesis. Compounds and inhibited elastase (IC: 292.25 ± 14.39 and 800.41 ± 5.86 μM, respectively), whereas compounds - inhibited tyrosinase with IC values in the range of 6.42 ~ 51.19 μM, respectively. In addition, compounds - and exhibited dose-dependent inhibition (70.4% ~ 91.0%) of melanogenesis at a concentration of 100 μM.

摘要

某些物种传统上被用于民间医学来治疗各种病症。在本研究中，从黑紫藜芦（Veratrum nigrum L. f. Nakai）的地上部分分离出了九种化合物，包括一种简单酚类化合物（）、三种芪类化合物（-）和五种黄酮类化合物（-）。这些化合物的结构通过光谱分析并与已报道数据进行比较得以阐明。总之，在该研究中所有报道的化合物均首次从黑紫藜芦中分离得到。其中，两种黄酮苷元三丝菌素（和）从未从藜芦属或延龄草科中分离得到。对乙醇提取物和分离出的化合物进行了对弹性蛋白酶、酪氨酸酶和黑色素合成的抑制作用评估。化合物和抑制弹性蛋白酶（IC：分别为292.25 ± 14.39和800.41 ± 5.86 μM），而化合物 - 抑制酪氨酸酶，IC值分别在6.42 ~ 51.19 μM范围内。此外，化合物 - 和在100 μM浓度下对黑色素生成表现出剂量依赖性抑制（70.4% ~ 91.0%）。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d381/10965189/4f5c74b365fd/tjc-47-06-1346f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d381/10965189/3ba34e471569/tjc-47-06-1346f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d381/10965189/c2a8dea1a65f/tjc-47-06-1346f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d381/10965189/3e7e123a3368/tjc-47-06-1346f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d381/10965189/4f5c74b365fd/tjc-47-06-1346f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d381/10965189/3ba34e471569/tjc-47-06-1346f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d381/10965189/c2a8dea1a65f/tjc-47-06-1346f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d381/10965189/3e7e123a3368/tjc-47-06-1346f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d381/10965189/4f5c74b365fd/tjc-47-06-1346f4.jpg

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