Aboulaghras Sara, Sahib Nargis, Bakrim Saad, Benali Taoufiq, Charfi Saoulajan, Guaouguaou Fatima-Ezzahrae, Omari Nasreddine El, Gallo Monica, Montesano Domenico, Zengin Gokhan, Taghzouti Khalid, Bouyahya Abdelhakim
Physiology and Physiopathology Team, Faculty of Sciences, Genomic of Human Pathologies Research, Mohammed V University in Rabat, Rabat 10100, Morocco.
Laboratoire d'Amélioration des Productions Agricoles, Biotechnologie et Environnement (LAPABE), Faculté des Sciences, Mohammed Premier University, Oujda 60000, Morocco.
Pharmaceuticals (Basel). 2022 Aug 7;15(8):973. doi: 10.3390/ph15080973.
A flavone, chrysoeriol is synthetized in several plant species. It comes from several natural sources, especially medicinal plants. The identification and isolation of this compound has been carried out and verified by several research teams using different spectral methods. It seems that the concentration of this molecule is variable and fluctuating depending on the source, the part extracted, the region, and the methods of extraction and characterization. The aim of this paper is to highlight the in vitro and in vivo pharmacological properties of chrysoeriol and to provide insight into its pharmacokinetics. Anticancer, anti-inflammatory, antibacterial, antifungal, anti-osteoporosis, anti-insecticide, and neuroprotective actions have been shown in a number of studies on this chemical. Different mechanisms in theses pharmacological effects include subcellular, cellular, and molecular targets. In vivo pharmacokinetic analysis has proved the good stability of this molecule, showing its promising potential to prevent or treat diseases including cancer, diabetes, inflammation, osteoporosis, Parkinson's disease, and cardiovascular diseases.
黄酮类化合物白杨黄素在多种植物物种中合成。它来源于多种天然来源，尤其是药用植物。几个研究团队已使用不同的光谱方法对该化合物进行了鉴定和分离，并得到了验证。该分子的浓度似乎因来源、提取部位、地区以及提取和表征方法而异，且波动不定。本文旨在突出白杨黄素的体外和体内药理学特性，并深入探讨其药代动力学。多项关于这种化学物质的研究已表明其具有抗癌、抗炎、抗菌、抗真菌、抗骨质疏松、抗杀虫和神经保护作用。这些药理作用的不同机制包括亚细胞、细胞和分子靶点。体内药代动力学分析已证明该分子具有良好的稳定性，显示出其在预防或治疗包括癌症、糖尿病、炎症、骨质疏松、帕金森病和心血管疾病在内的疾病方面的潜在前景。
