Machado Marisa, Sousa Maria do Céu, Salgueiro Lígia, Cavaleiro Carlos
Centro de Estudos Farmacêuticos/Faculdade de Farmácia, Universidade de Coimbra, 3000-548, Coimbra, Portugal.
Nat Prod Commun. 2010 Jan;5(1):137-41.
Giardia lamblia is one of the most important worldwide causes of intestinal infections produced by protozoa. Current therapy for giardiasis is unsatisfactory due to high incidence of undesirable side effects and significant failure in clearing parasites from the gastrointestinal tract. In the search for new therapeutic agents, we report on the effect of several essential oils on G. lamblia growth. Among eighteen tested essential oils, those with phenolic compositions were the most active, particularly if containing high contents of carvacrol, such as Thymbra capitata and Origanum virens (IC50 values of 71 and 85 microg x mL(-1), respectively). The oils from Syzygium aromaticum and Thymus zygis subsp. sylvestris (IC50 values from 100 to 200 microg x mL(-1)), as well as, those from Mentha x piperita and Lippia graveolens (IC50 values over 200 microg x mL(-1)) were less active. Results support the concept that several essential oils or some of their constituents may be useful in the clinical management of Giardia infections.
蓝氏贾第鞭毛虫是全球范围内由原生动物引起的肠道感染的最重要病因之一。由于不良副作用发生率高且在清除胃肠道寄生虫方面显著失败，目前治疗贾第虫病的方法并不令人满意。在寻找新的治疗药物的过程中，我们报告了几种精油对蓝氏贾第鞭毛虫生长的影响。在测试的18种精油中，具有酚类成分的精油活性最强，特别是那些含有高含量香芹酚的精油，如头状百里香和绿牛至（IC50值分别为71和85微克·毫升⁻¹）。丁香和齐氏百里香亚种的精油（IC50值为100至200微克·毫升⁻¹），以及薄荷和小叶过江藤的精油（IC50值超过200微克·毫升⁻¹）活性较低。结果支持这样一种观点，即几种精油或其某些成分可能有助于贾第虫感染的临床治疗。
