Kicha Alla A, Ha Dinh T, Ivanchina Natalia V, Malyarenko Timofey V, Kalinovsky Anatoly I, Dmitrenok Pavel S, Ermakova Svetlana P, Malyarenko Olesya S, Hung Nguyen A, Thuy Tran T T, Long Pham Q
G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far East Branch of the Russian Academy of Sciences, Pr. 100-let Vladivostoku 159, 690022, Vladivostok, Russia.
Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Nighiado, Cau Giay, Hanoi, Vietnam.
Chem Biodivers. 2018 Mar;15(3):e1700553. doi: 10.1002/cbdv.201700553. Epub 2018 Mar 2.
Six new polyhydroxysteroidal glycosides, anthenosides S1 - S6 (1 - 6), along with a mixture of two previously known related glycosides, 7 and 8, were isolated from the methanolic extract of the starfish Anthenea sibogae. The structures of 1 - 6 were established by NMR and HR-ESI-MS techniques as well as by chemical transformations. All new compounds have a 5α-cholest-8(14)-ene-3α,6β,7β,16α-tetrahydroxysteroidal nucleus and differ from majority of starfish glycosides in positions of carbohydrate moieties at C(7) and C(16) (1 - 4, 6) or only at C(16) (5). The 4-O-methyl-β-d-glucopyranose residue (2) and Δ -cholestane side chain (3) have not been found earlier in the starfish steroidal glycosides. The mixture of 7 and 8 slightly inhibited the proliferation of human breast cancer T-47D cells and decreased the colony size in the colony formation assay.
从多棘海盘车（Anthenea sibogae）的甲醇提取物中分离出六种新的多羟基甾体糖苷，即海盘车苷S1 - S6（1 - 6），以及两种先前已知的相关糖苷的混合物7和8。通过核磁共振（NMR）、高分辨电喷雾电离质谱（HR-ESI-MS）技术以及化学转化确定了1 - 6的结构。所有新化合物都具有5α-胆甾-8(14)-烯-3α,6β,7β,16α-四羟基甾体核，并且在C(7)和C(16)（1 - 4, 6）或仅在C(16)（5）处的碳水化合物部分位置与大多数海星糖苷不同。4-O-甲基-β-D-吡喃葡萄糖残基（2）和Δ-胆甾烷侧链（3）在海星甾体糖苷中尚未被发现。7和8的混合物在集落形成试验中轻微抑制人乳腺癌T-47D细胞的增殖并减小集落大小。
