抗原性胃癌硫酸多糖与化生“肠”型硫酸多糖的鉴别。
Differentiation of antigenic gastric cancer sulphopolysaccharides from metaplastic 'intestinal' type sulphopolysaccharides.
作者信息
Häkkinen I P
机构信息
Department of Physiology, The Medical Clinic and The Surgical Clinic, University of Turku, Turku, Finland.
出版信息
Scand J Gastroenterol. 1967;2(1):39-43. doi: 10.3109/00365526709180045.
Sulphopolysaccharides, isolated from gastric juice of patients with pernicious anemia or gastric cancer, have been characterized immunologically using corresponding rabbit immunosera. Gastric juice sulphopolysaccharides differ from their normal form in the following conditions: a) when there is intestinal type metaplastic tissue in the gastric epithelium; b) in the presence of gastric cancer. Efforts to differentiate between these types by the absorption technique using rabbit immunosera were successful, and it was possible to demonstrate an antigenic determinant in sulphopolysaccharides from cancerous gastric juice not present in controls with benign intestinal type heterotopia as in pernicious anemia.
从恶性贫血或胃癌患者胃液中分离出的硫多糖，已使用相应的兔抗血清进行了免疫学特性鉴定。胃液硫多糖在以下情况下与其正常形式不同：a）胃上皮存在肠化生组织时；b）存在胃癌时。利用兔抗血清通过吸收技术区分这些类型的尝试取得了成功，并且有可能证明癌性胃液中的硫多糖存在一种抗原决定簇，而在患有良性肠化生的对照中（如恶性贫血患者）不存在这种抗原决定簇。
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