Eyigör Sibel, Karapolat Hale, Adanur Hilal, Kirazli Yeşim
Physical Therapy and Rehabilitation Department, Ege University Faculty of Medicine, 35100 Bornova, Izmir, Turkey.
Cases J. 2009 Aug 14;2:6281. doi: 10.1186/1757-1626-0002-0000006281.
The SAPHO syndrome (synovitis, acne, pustulosis, hyperostosis, osteomyelitis) is a rare painful disorder, usually with a good long-term prognosis. Its etiology remains unclear, and various treatment regimens frequently fail to control the disease.
A 46-year-old Caucasian female was referred for anterior chest wall and back pain. Physical examination was unremarkable except for skin lesions noted on soles of both feet, extremities and the face. A thoracic magnetic resonance imaging study demonstrated a lesion characterized with bone marrow edema and proliferation of soft tissue in the sternum. A brain MRI was requested secondary to the elevated prolactin level which was compatible with empty sella syndrome.
The case presented here has the unique feature of adrenal deficiency presenting alongside the SAPHO syndrome and is presented as the first case reported. This syndrome could become complicated with different organ system involvement other than bone and skin. There is a need further studies that will explore the weak relationship between SAPHO syndrome and adrenal deficiency.
滑膜炎、痤疮、脓疱病、骨肥厚、骨髓炎综合征（SAPHO综合征）是一种罕见的疼痛性疾病，通常具有良好的长期预后。其病因尚不清楚，各种治疗方案常常无法控制该病。
一名46岁的白种女性因前胸壁和背部疼痛前来就诊。体格检查无异常，仅在双足底、四肢及面部发现皮肤病变。胸部磁共振成像研究显示胸骨有骨髓水肿和软组织增生的病变。因催乳素水平升高并符合空蝶鞍综合征，故进行了脑部MRI检查。
此处报告的病例具有肾上腺功能减退与SAPHO综合征同时出现的独特特征，是首例报告病例。该综合征可能会因骨骼和皮肤以外的不同器官系统受累而变得复杂。有必要进一步开展研究，探索SAPHO综合征与肾上腺功能减退之间的微弱关系。
