Rozin A P, Nahir A M
The B. Shine Department of Rheumatology, Rambam Medical Center and B. Rappaport Faculty of Medicine, Israel-Technion Institute of Technology, 9602, Haifa 31096, Israel.
Clin Rheumatol. 2007 May;26(5):817-20. doi: 10.1007/s10067-006-0274-6. Epub 2006 Apr 7.
The etiology of the synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome remains unclear. Infectious factors are proposed to be relevant in the etiopathogenesis of the disease. To our knowledge, this is the first reported case of a proposed relationship between Staphylococcus aureus cultured from plantar pustule and SAPHO syndrome, which was successfully treated with co-trimoxazole (CTM) (sulfamethoxazole/trimetoprim). CTM might be the drug of choice for therapy for SAPHO syndrome because of combined antibiotic and immunomodulatory properties. Hypersensitivity testing of the medication in vitro was performed to identify, in the preclinical stage, the hypersensitivity reaction to CTM, which may have been severe.
滑膜炎、痤疮、脓疱病、骨肥厚和骨炎（SAPHO）综合征的病因仍不清楚。有观点认为感染因素与该疾病的发病机制相关。据我们所知，这是首例报道的足底脓疱培养出的金黄色葡萄球菌与SAPHO综合征之间存在推测关系的病例，该病例用复方新诺明（CTM）（磺胺甲恶唑/甲氧苄啶）成功治愈。由于具有抗生素和免疫调节双重特性，CTM可能是治疗SAPHO综合征的首选药物。在临床前阶段对该药物进行了体外过敏试验，以确定对CTM可能出现的严重过敏反应。
