Taleb Amina, Ismaili Nabil, Belbaraka Rhizlane, Bensouda Abdellah, Elghissassi Ibrahim, Elmesbahi Omar, Droz Jean Pierre, Errihani Hassan
Department of Medical Oncology, National Institute of Oncology, Rabat, Morocco.
Cases J. 2009 Aug 11;2:8875. doi: 10.1186/1757-1626-0002-0000008875.
Primary lymphoma of the prostate is very rare. In this paper we present a case of early stage non-Hodgkin lymphoma of the prostate managed with six cycles of rituximab-based chemotherapy, and review the related literature.
An 84-year-old man was admitted to our hospital having signs and symptoms suggestive of prostatic disease for 3 years. Histological and immunocytochemical studies of trans-urethral biopsy of the prostate showed diffuse large B-cell lymphoma. Radiological assessment of disease confirmed the diagnosis of early stage lymphoma of the prostate. The patient was managed by 6 of rituximab 375 mg/m2 on day 1, cyclophosphamide 750 mg/m2 on day 1, doxorubicin 50 mg/m2 on day 1, vincristine 1.4 mg/m2 on day 1, and prednisone 50 mg/m2 on days 1 to 5 with complete clinical and radiological response. He remained disease free, until now, 30 months after the end of chemotherapy.
According to the literature, the treatment and prognosis of primary lymphoma of the prostate is the same as that of other nodal lymphomas. Rituximab-based regimen should be considered in the management of prostatic diffuse large B-cell lymphoma.
原发性前列腺淋巴瘤非常罕见。本文报告一例早期前列腺非霍奇金淋巴瘤患者，采用了六个周期的利妥昔单抗为基础的化疗方案进行治疗，并对相关文献进行了综述。
一名84岁男性因有前列腺疾病的体征和症状3年而入住我院。经尿道前列腺活检的组织学和免疫细胞化学研究显示为弥漫性大B细胞淋巴瘤。疾病的影像学评估证实了早期前列腺淋巴瘤的诊断。患者接受了六个周期的治疗，第1天使用利妥昔单抗375mg/m²，第1天使用环磷酰胺750mg/m²，第1天使用多柔比星50mg/m²，第1天使用长春新碱1.4mg/m²，第1至5天使用泼尼松50mg/m²，临床和影像学均完全缓解。化疗结束30个月后，截至目前他仍无疾病复发。
根据文献，原发性前列腺淋巴瘤的治疗和预后与其他淋巴结淋巴瘤相同。在前列腺弥漫性大B细胞淋巴瘤的治疗中应考虑以利妥昔单抗为基础的治疗方案。
