内毒素血症和脓毒症中的组织因子细胞来源。
Cellular sources of tissue factor in endotoxemia and sepsis.
机构信息
Hematology and Oncology Division, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27516, USA.
出版信息
Thromb Res. 2010 Apr;125 Suppl 1:S70-3. doi: 10.1016/j.thromres.2010.01.042. Epub 2010 Feb 24.
Abstract
Sepsis is a systemic host response to infection by pathogenic microorganisms. Activation of the coagulation cascade during endotoxemia and sepsis leads to disseminated intravascular coagulation. This review focuses on tissue factor expression by hematopoietic and non-hematopoietic cells and its contribution to the activation of coagulation during endotoxemia and sepsis.
摘要
脓毒症是机体对感染病原微生物的全身反应。内毒素血症和脓毒症期间凝血级联的激活可导致弥散性血管内凝血。本综述重点关注了造血细胞和非造血细胞的组织因子表达及其在内毒素血症和脓毒症期间凝血激活中的作用。
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