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采用乙状窦后入路和经迷路入路的Ⅲ-Ⅳ期前庭神经鞘瘤手术后患者的生活质量

Quality of life of patients following stages III-IV vestibular schwannoma surgery using the retrosigmoid and translabyrinthine approaches.

作者信息

Rameh Charbel, Magnan Jacques

机构信息

Department of Otolaryngology - Head and Neck Surgery, Nord University Hospital, Marseille, France.

出版信息

Auris Nasus Larynx. 2010 Oct;37(5):546-52. doi: 10.1016/j.anl.2010.01.004. Epub 2010 Feb 24.

Abstract

OBJECTIVE

Surgery is an unquestionable treatment for stages III and IV vestibular schwannomas. The postoperative quality of life (QOL) remains the main issue of concern. In this study, we have evaluated the postoperative QOL of these patients operated by two surgical approaches, the retrosigmoid approach (RSA) and the translabyrinthine approach (TLA).

MATERIALS AND METHODS

This is a retrospective review of 101 stages III and IV vestibular schwannoma cases operated between 2000 and 2006 at our center by the senior author (J.M.). The Short Form SF-36 questionnaire and additional questions were sent to the patients. Comparison was made between the patient group and a control group to evaluate the postoperative QOL.

RESULTS

The response rate was 67.3%. There were 44 males and 57 females. The average follow up was 5.9 years. 59 patients were operated using the TLA and 42 using the RSA. Both patient groups had significantly lower scores on the questionnaire when compared to the normal population, and thus a less satisfactory QOL. Pain was the symptom that correlated most with poorer scores on the SF-36 questionnaire, although it was the least frequent symptom reported by the patients. Unsteadiness and facial weakness were the least bothersome complaints. Facial weakness did not correlate with a poorer QOL.

CONCLUSION

Operated stages III-IV vestibular schwannoma patients suffer from a certain degree of QOL deterioration compared to normal controls. Hearing deficit was the most prevalent symptom. Pain was the least frequent but the most bothersome and with the highest correlation with a poorer QOL. Interestingly, unsteadiness and facial weakness were the least bothersome complaints. Facial weakness did not correlate with a poorer QOL.

摘要

目的

手术是治疗Ⅲ期和Ⅳ期前庭神经鞘瘤的一种无可争议的方法。术后生活质量(QOL)仍然是主要关注的问题。在本研究中,我们评估了采用乙状窦后入路(RSA)和经迷路入路(TLA)这两种手术方法治疗的这些患者的术后生活质量。

材料与方法

这是一项对2000年至2006年期间在我们中心由资深作者(J.M.)手术治疗的101例Ⅲ期和Ⅳ期前庭神经鞘瘤病例的回顾性研究。向患者发送了简短形式的SF - 36问卷及附加问题。将患者组与对照组进行比较以评估术后生活质量。

结果

回复率为67.3%。有44名男性和57名女性。平均随访时间为5.9年。59例患者采用TLA手术,42例采用RSA手术。与正常人群相比,两个患者组在问卷上的得分均显著较低,因此生活质量不太令人满意。疼痛是与SF - 36问卷得分较差相关性最高的症状,尽管它是患者报告最少的症状。步态不稳和面部无力是最不困扰患者的症状。面部无力与较差的生活质量无关。

结论

与正常对照组相比,接受手术治疗的Ⅲ - Ⅳ期前庭神经鞘瘤患者的生活质量有一定程度的下降。听力障碍是最普遍的症状。疼痛是最少疼痛是最少见但最困扰患者且与较差生活质量相关性最高的症状。有趣的是,步态不稳和面部无力是最不困扰患者的症状。面部无力与较差的生活质量无关。

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