Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892-1616, USA.
Science. 2010 Feb 26;327(5969):1098-102. doi: 10.1126/science.1178334.
CD4+ T cells are critical for host defense but are also major drivers of immune-mediated disease. These T cells specialize to become distinct subsets and produce restricted patterns of cytokines, which are tailored to combat various microbial pathogens. Although classically viewed as distinct lineages, recent work calls into question whether helper CD4+ T cell subsets are more appropriately viewed as terminally differentiated cells or works in progress. Herein, we review recent advances that pertain to this topic and the mechanisms that contribute to helper CD4+ T cell commitment and plasticity. The therapeutic implications of these new findings are also considered.
CD4+ T 细胞对于宿主防御至关重要，但也是免疫介导疾病的主要驱动因素。这些 T 细胞专门分化为不同的亚群，并产生特定模式的细胞因子，以针对各种微生物病原体。尽管传统上被视为不同的谱系，但最近的研究工作对辅助性 CD4+ T 细胞亚群是否更适合被视为终末分化细胞或正在进行的工作提出了质疑。本文综述了与这一主题相关的最新进展，以及有助于辅助性 CD4+ T 细胞定型和可塑性的机制。还考虑了这些新发现的治疗意义。
