Menzies Research Institute, University of Tasmania, Hobart, Tasmania, Australia.
Diabetes Care. 2010 May;33(5):1128-33. doi: 10.2337/dc09-1940. Epub 2010 Feb 25.
To examine the association between depressive disorder and insulin resistance in a sample of young adults using the Composite International Diagnostic Interview to ascertain depression status.
Cross-sectional data were collected from 1,732 participants aged between 26 and 36 years. Insulin resistance was derived from blood chemistry measures of fasting insulin and glucose using the homeostasis model assessment method. Those identified with mild, moderate, or severe depression were classified as having depressive disorder.
The 12-month prevalence of depressive disorder was 5.4% among men and 11.7% among women. In unadjusted models mean insulin resistance was 17.2% (95% CI 0.7-36.0%, P = 0.04) higher in men and 11.4% (1.5-22.0%, P = 0.02) higher in women with depressive disorder. After adjustment for behavioral and dietary factors, the increased level of insulin resistance associated with depressive disorder was 13.2% (-3.1 to 32.3%, P = 0.12) in men and 6.1% (-4.1 to 17.4%, P = 0.25) in women. Waist circumference was identified as a mediator in the relationship between depression and insulin resistance, reducing the beta coefficient in the fully adjusted models in men by 38% and in women by 42%.
A positive association was found between depressive disorder and insulin resistance in this population-based sample of young adult men and women. The association seemed to be mediated partially by waist circumference.
使用复合国际诊断访谈来确定抑郁状态，在年轻成年人样本中检查抑郁障碍与胰岛素抵抗之间的关联。
从年龄在 26 至 36 岁之间的 1732 名参与者中收集横断面数据。胰岛素抵抗源自空腹胰岛素和葡萄糖的血液化学测量，使用稳态模型评估方法得出。将轻度、中度或重度抑郁的人归类为患有抑郁障碍。
男性中抑郁障碍的 12 个月患病率为 5.4%，女性中为 11.7%。在未调整的模型中，患有抑郁障碍的男性的平均胰岛素抵抗水平高 17.2%（95%CI 0.7-36.0%，P=0.04），女性高 11.4%（1.5-22.0%，P=0.02）。在调整行为和饮食因素后，与抑郁障碍相关的胰岛素抵抗水平升高 13.2%（-3.1 至 32.3%，P=0.12）在男性中，6.1%（-4.1 至 17.4%，P=0.25）在女性中。腰围被确定为抑郁和胰岛素抵抗之间关系的中介因素，在男性的完全调整模型中，该系数降低了 38%，在女性中降低了 42%。
在这个基于人群的年轻成年男性和女性样本中，发现抑郁障碍与胰岛素抵抗之间存在正相关。这种关联似乎部分通过腰围来介导。
