Park Sun Kyun, Son Hyo Kyung, Lee Sung Kook, Kang Jung Ho, Chang Yoon Seok, Jacobs David R, Lee Duk Hee
Department of Preventive Medicine, School of Medicine, Kyungpook National University, Korea.
J Prev Med Public Health. 2010 Jan;43(1):1-8. doi: 10.3961/jpmph.2010.43.1.1.
This study was performed to investigate if organochlorine pesticides (OCPs) were associated with metabolic syndrome and insulin resistance among non-diabetes.
Among subjects who participated in a community-based health survey, 50 non-diabetic subjects with metabolic syndrome and 50 normal controls were selected. Insulin resistance was measured by the homeostasis model assessment (HOMA-IR). Eight OCPs were selected.
After adjusting for confounders except for body mass index (BMI), beta-hexachlorocyclohexane (beta-HCH) and heptachlor epoxide were positively associated with metabolic syndrome. Odds ratios across tertiles of beta-HCH and heptachlor epoxide were 1.0, 3.2 and 4.4, and 1.0, 4.0 and 6.0, respectively (p for trend = 0.01 and <0.01). After additional adjustment for body mass index (BMI), heptachlor epoxide still showed an increasing trend with adjusted odds ratios of 1.0, 4.1, and 4.6 (p for trend = 0.10). When the five components of metabolic syndrome (with the definition of high fasting glucose (> or =100 mg/dL)) were separately analyzed, all components were positively, but not significantly, associated with heptachlor epoxide. As the serum concentration of heptachlor epoxide increased, HOMA-IR increased significantly in subjects with metabolic syndrome even after adjusting for BMI (p value <0.05 and <0.01).
Despite the small sample size, this study suggests that the background exposure to some OCPs may be associated with metabolic syndrome.
本研究旨在调查有机氯农药（OCPs）与非糖尿病患者的代谢综合征及胰岛素抵抗是否相关。
在参与社区健康调查的受试者中，选取50名患有代谢综合征的非糖尿病患者和50名正常对照者。采用稳态模型评估法（HOMA-IR）测量胰岛素抵抗。选取了8种有机氯农药。
在调整除体重指数（BMI）以外的混杂因素后，β-六氯环己烷（β-HCH）和环氧七氯与代谢综合征呈正相关。β-HCH和环氧七氯三分位数的比值比分别为1.0、3.2和4.4，以及1.0、4.0和6.0（趋势p值=0.01和<0.01）。在进一步调整体重指数（BMI）后，环氧七氯仍呈上升趋势，调整后的比值比为1.0、4.1和4.6（趋势p值=0.10）。当对代谢综合征的五个组分（空腹血糖高（≥100mg/dL）的定义）进行单独分析时，所有组分均与环氧七氯呈正相关，但无统计学意义。随着环氧七氯血清浓度的升高，即使在调整BMI后，代谢综合征患者的HOMA-IR也显著升高（p值<0.05和<0.01）。
尽管样本量较小，但本研究表明，某些有机氯农药的背景暴露可能与代谢综合征有关。
