Salcedo-Bellido Inmaculada, Amaya Esperanza, Pérez-Díaz Celia, Soler Anabel, Vela-Soria Fernando, Requena Pilar, Barrios-Rodríguez Rocío, Echeverría Ruth, Pérez-Carrascosa Francisco M, Quesada-Jiménez Raquel, Martín-Olmedo Piedad, Arrebola Juan Pedro
Departamento de Medicina Preventiva y Salud Pública, Universidad de Granada, 18071 Granada, Spain.
Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), 28029 Madrid, Spain.
Int J Environ Res Public Health. 2022 Mar 11;19(6):3344. doi: 10.3390/ijerph19063344.
To identify bioaccumulation patterns of α-, β- hexachlorocyclohexane (HCH) and dicofol in relation to sociodemographic, dietary, and lifestyle factors, adipose tissue samples of 387 subjects from GraMo cohort in Southern Spain were analyzed. Potential predictors of these organochlorine pesticides (OCP) levels were collected by face-to-face interviews and assessed by multivariable linear and logistic regression. OCPs were detected in 84.2% (β-HCH), 21.7% (α-HCH), and 19.6% (dicofol) of the population. β-HCH levels were positively related to age, body mass index (BMI), mother's occupation in agriculture during pregnancy, living in Poniente and Alpujarras, white fish, milk and water consumption, and negatively related to being male, living near to an agricultural area, working ≥10 years in agriculture, and beer consumption. Detectable α-HCH levels were positively related to age, BMI, milk consumption, mother's occupation in agriculture during pregnancy, and negatively with residence in Poniente and Alpujarras, Granada city, and Granada Metropolitan Area. Residence near to an agricultural area, smoking habit, white fish and water consumption, and living in Poniente and Alpujarras, Granada city and Granada Metropolitan Area were negatively associated with detectable dicofol levels. Our study revealed different bioaccumulation patterns of α, β-HCH and dicofol, probably due to their dissimilar period of use, and emphasize the need for assessing the exposure to frequently overlooked pollutants.
为了确定α-、β-六氯环己烷（HCH）和三氯杀螨醇的生物累积模式与社会人口统计学、饮食和生活方式因素之间的关系，对来自西班牙南部格拉莫队列的387名受试者的脂肪组织样本进行了分析。通过面对面访谈收集这些有机氯农药（OCP）水平的潜在预测因素，并通过多变量线性和逻辑回归进行评估。在84.2%（β-六氯环己烷）、21.7%（α-六氯环己烷）和19.6%（三氯杀螨醇）的人群中检测到了有机氯农药。β-六氯环己烷水平与年龄、体重指数（BMI）、母亲孕期从事农业工作、居住在西部地区和阿尔普哈拉地区、食用白鱼、牛奶和水呈正相关，与男性、居住在农业区附近、从事农业工作≥10年以及饮用啤酒呈负相关。可检测到的α-六氯环己烷水平与年龄、BMI、牛奶消费、母亲孕期从事农业工作呈正相关，与居住在西部地区和阿尔普哈拉地区、格拉纳达市和格拉纳达都会区呈负相关。居住在农业区附近、吸烟习惯、食用白鱼和水以及居住在西部地区和阿尔普哈拉地区、格拉纳达市和格拉纳达都会区与可检测到的三氯杀螨醇水平呈负相关。我们的研究揭示了α、β-六氯环己烷和三氯杀螨醇不同的生物累积模式，这可能是由于它们不同的使用时期，并强调需要评估对经常被忽视的污染物的暴露情况。
