Division of Molecular Neurobiology, Department of Neuroscience, Karolinska Institutet, Stockholm S-17177, Sweden.
Dev Neurobiol. 2010 Apr;70(5):323-31. doi: 10.1002/dneu.20773.
Neurotrophic factors play important roles in the development and function of both neuronal and glial elements of the central and peripheral nervous systems. Their functional diversity is in part based on their ability to interact with alternative complexes of receptor molecules. This review focuses on our current understanding of the mechanisms that govern the assembly and activation of neurotrophic factor receptor complexes. The realization that many, if not the majority, of these complexes exist in a preassembled form at the plasma membrane has forced the revision of classical ligand-mediated oligomerization models, and led to the discovery of novel mechanisms of receptor activation and generation of signaling diversity which are likely to be shared by many different classes of receptors.
神经营养因子在中枢和外周神经系统的神经元和神经胶质成分的发育和功能中发挥着重要作用。它们的功能多样性部分基于它们与受体分子的替代复合物相互作用的能力。本综述重点介绍了我们目前对调节神经营养因子受体复合物组装和激活的机制的理解。许多（如果不是大多数）这些复合物以预组装形式存在于质膜上的这一认识，迫使人们修正了经典的配体介导寡聚化模型，并发现了受体激活和产生信号多样性的新机制，这些机制可能被许多不同类别的受体共享。
