秀丽隐杆线虫：用于轴突再生研究的新型模式生物。
Caenorhabditis elegans: a new model organism for studies of axon regeneration.
机构信息
Division of Biological Sciences, Section of Neurobiology, University of California San Diego, La Jolla, California 92093, USA.
出版信息
Dev Dyn. 2010 May;239(5):1460-4. doi: 10.1002/dvdy.22253.
Abstract
Axonal regeneration in Caenorhabditis elegans was first reported five years ago. Individual green fluorescent protein-labeled axons can be severed using laser microsurgery and their regrowth followed in vivo. Several neuron types display robust regrowth after injury, including motor and sensory neurons. The small size and transparency of C. elegans make possible large-scale genetic and pharmacological screens for regeneration phenotypes.
摘要
五年前首次报道了秀丽隐杆线虫中的轴突再生。可以使用激光显微手术切断单个绿色荧光蛋白标记的轴突，并在体内跟踪其再生情况。几种神经元类型在受伤后表现出很强的再生能力，包括运动神经元和感觉神经元。秀丽隐杆线虫的体型小且透明，这使得大规模的遗传和药理学筛选再生表型成为可能。
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2
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