秀丽隐杆线虫中的轴突再生。
Axon regeneration in C. elegans.
作者信息
Hammarlund Marc, Jin Yishi
机构信息
Department of Genetics and Program in Cellular Neuroscience, Neurodegeneration, and Repair, Yale University, New Haven, CT 06520, United States.
Section of Neurobiology and Department of Cellular and Molecular Medicine, Howard Hughes Medical Institute, University of California, San Diego, CA 92093, United States.
出版信息
Curr Opin Neurobiol. 2014 Aug;27:199-207. doi: 10.1016/j.conb.2014.04.001. Epub 2014 May 4.
Abstract
Single axon transection by laser surgery has made Caenorhabditis elegans a new model for axon regeneration. Multiple conserved molecular signaling modules have been discovered through powerful genetic screening. In vivo imaging with single cell and axon resolution has revealed unprecedented cellular dynamics in regenerating axons. Information from C. elegans has greatly expanded our knowledge of the molecular and cellular mechanisms of axon regeneration.
摘要
通过激光手术对单个轴突进行横切，使秀丽隐杆线虫成为轴突再生的新模型。通过强大的基因筛选发现了多个保守的分子信号模块。具有单细胞和轴突分辨率的体内成像揭示了再生轴突中前所未有的细胞动态。来自秀丽隐杆线虫的信息极大地扩展了我们对轴突再生分子和细胞机制的认识。
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本文引用的文献
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