Section of General Surgery, Department of Surgery, University of Chicago Medical Center, Chicago, Illinois 60637, USA.
J Surg Oncol. 2010 Mar 15;101(4):299-304. doi: 10.1002/jso.21479.
Patients with locally advanced esophageal carcinoma have consistently poor survival following surgery with associated high systemic and local-regional failure rates. Neoadjuvant therapeutic strategies have been employed in an attempt to improve outcome with variable success. Randomized trials of either neoadjuvant chemotherapy or chemoradiotherapy have shown conflicting results regarding survival and local-regional control. Future efforts should focus on identifying novel agents and targets to improve therapeutic efficacy.
局部晚期食管癌患者手术后的总体生存情况较差，伴有较高的全身和局部区域失败率。新辅助治疗策略已被应用于试图改善预后，但效果不一。新辅助化疗或放化疗的随机试验在生存和局部区域控制方面显示出相互矛盾的结果。未来的研究应集中于确定新的药物和靶点以提高治疗效果。
