Department of Radiology, Northwestern University, Chicago, Illinois 60611, USA.
J Magn Reson Imaging. 2010 Mar;31(3):645-54. doi: 10.1002/jmri.22058.
To evaluate the effectiveness of flow-sensitive dephasing (FSD) magnetization preparation in improving blood signal suppression of three-dimensional (3D) turbo spin-echo (TSE) sequence (SPACE) for isotropic high-spatial-resolution carotid arterial wall imaging at 3T.
The FSD-prepared SPACE sequence (FSD-SPACE) was implemented by adding two identical FSD gradient pulses right before and after the first refocusing 180 degrees -pulse of the SPACE sequence in all three orthogonal directions. Nine healthy volunteers were imaged at 3T with SPACE, FSD-SPACE, and multislice T2-weighted 2D TSE coupled with saturation band (SB-TSE). Apparent carotid wall-lumen contrast-to-noise ratio (aCNR(w-l)) and apparent lumen area (aLA) at the locations with residual-blood (rb) signal shown on SPACE images were compared between SPACE and FSD-SPACE. Carotid aCNR(w-l) and lumen (LA) and wall area (WA) measured from FSD-SPACE were compared to those measured from SB-TSE.
Plaque-mimicking flow artifacts identified in seven carotids on SPACE images were eliminated on FSD-SPACE images. The FSD preparation resulted in slightly reduced aCNR(w-l) (P = 0.025), but significantly improved aCNR between the wall and rb regions (P < 0.001) and larger aLA (P < 0.001). Compared to SB-TSE, FSD-SPACE offered comparable aCNR(w-l) with much higher spatial resolution, shorter imaging time, and larger artery coverage. The LA and WA measurements from the two techniques were in good agreement based on intraclasss correlation coefficient (0.988 and 0.949, respectively; P < 0.001) and Bland-Altman analyses.
FSD-SPACE is a time-efficient 3D imaging technique for carotid arterial wall with superior spatial resolution and blood signal suppression.
评估流动敏感去相位（FSD）磁化准备在提高三维（3D）涡轮自旋回波（TSE）序列（SPACE）的血液信号抑制方面的有效性，用于 3T 下各向同性高空间分辨率颈动脉壁成像。
在所有三个正交方向上，FSD 准备的 SPACE 序列（FSD-SPACE）通过在 SPACE 序列的第一个重聚焦 180 度 - 脉冲之前和之后添加两个相同的 FSD 梯度脉冲来实现。在 3T 下，9 名健康志愿者分别接受了 SPACE、FSD-SPACE 和多层 T2 加权二维 TSE 与饱和带（SB-TSE）联合扫描。比较了 SPACE 图像上显示残留血（rb）信号的位置处颈动脉壁-腔对比噪声比（aCNR（w-l））和表观管腔面积（aLA）在 SPACE 和 FSD-SPACE 之间的差异。比较 FSD-SPACE 测量的颈动脉 aCNR（w-l）和管腔（LA）和壁面积（WA）与 SB-TSE 测量的结果。
SPACE 图像上识别出的七种颈动脉斑块模拟流动伪影在 FSD-SPACE 图像上被消除。FSD 准备导致 aCNR（w-l）略有降低（P = 0.025），但显著提高了壁与 rb 区域之间的 aCNR（P < 0.001）和更大的 aLA（P < 0.001）。与 SB-TSE 相比，FSD-SPACE 提供了具有更高空间分辨率、更短成像时间和更大动脉覆盖范围的可比 aCNR（w-l）。两种技术的 LA 和 WA 测量值基于组内相关系数（分别为 0.988 和 0.949；P < 0.001）和 Bland-Altman 分析具有良好的一致性。
FSD-SPACE 是一种高效的颈动脉壁 3D 成像技术，具有更高的空间分辨率和血液信号抑制效果。
