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鉴定与表型差异相关的功能模块：网络拓扑结构的影响。

Identification of functional modules that correlate with phenotypic difference: the influence of network topology.

机构信息

Bioinformatics Program, Boston University, 24 Cummington Street, Boston, MA 02215, USA.

出版信息

Genome Biol. 2010;11(2):R23. doi: 10.1186/gb-2010-11-2-r23. Epub 2010 Feb 26.

DOI:10.1186/gb-2010-11-2-r23
PMID:20187943
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2872883/
Abstract

One of the important challenges to post-genomic biology is relating observed phenotypic alterations to the underlying collective alterations in genes. Current inferential methods, however, invariably omit large bodies of information on the relationships between genes. We present a method that takes account of such information - expressed in terms of the topology of a correlation network - and we apply the method in the context of current procedures for gene set enrichment analysis.

摘要

后基因组生物学面临的重要挑战之一是将观察到的表型改变与潜在的基因集体改变联系起来。然而，目前的推理方法总是忽略了大量关于基因之间关系的信息。我们提出了一种考虑这种信息的方法 - 用相关网络拓扑的术语来表示 - 并将该方法应用于当前基因集富集分析程序的背景下。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de36/2872883/bb50a77b296e/gb-2010-11-2-r23-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de36/2872883/dbc2fe0ae965/gb-2010-11-2-r23-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de36/2872883/d14b512da64c/gb-2010-11-2-r23-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de36/2872883/cf1e143dceb4/gb-2010-11-2-r23-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de36/2872883/bb50a77b296e/gb-2010-11-2-r23-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de36/2872883/dbc2fe0ae965/gb-2010-11-2-r23-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de36/2872883/d14b512da64c/gb-2010-11-2-r23-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de36/2872883/cf1e143dceb4/gb-2010-11-2-r23-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de36/2872883/bb50a77b296e/gb-2010-11-2-r23-4.jpg

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