Department of Nutritional Science, Fu Jen Catholic University, no. 510 Jhongjheng Road, Sinjhuang City, Taipei County 24205, Taiwan.
Br J Nutr. 2010 Jul;104(1):67-75. doi: 10.1017/S0007114510000310. Epub 2010 Mar 1.
Diets that ameliorate the adverse effects of uric acid (UA) on renal damage deserve attention. The effects of casein or soya protein combined with palm or safflower-seed oil on various serum parameters and renal histology were investigated on hyperuricaemic rats. Male Wistar rats administered with oxonic acid and UA to induce hyperuricaemia were fed with casein or soya protein plus palm- or safflower-seed oil-supplemented diets. Normal rats and hyperuricaemic rats with or without allopurinol treatment (150 mg/l in drinking water) were fed with casein plus maize oil-supplemented diets. After 8 weeks, allopurinol treatment and soya protein plus safflower-seed oil-supplemented diet significantly decreased serum UA in hyperuricaemic rats (one-way ANOVA; P < 0.05). In addition, soya protein and casein attenuated hyperuricaemia-induced decreases in serum albumin and insulin, respectively (two-way ANOVA; P < 0.05). Safflower-seed oil significantly decreased serum TAG and UA, whereas palm oil significantly increased serum cholesterol, TAG, blood urea N and creatinine. However, soya protein significantly decreased renal NO and nitrotyrosine and palm oil significantly decreased renal nitrotyrosine, TNF-alpha and interferon-gamma and increased renal transforming growth factor-beta. Casein with safflower-seed oil significantly attenuated renal tubulointerstitial nephritis, crystals and fibrosis. Comparing casein v. soya protein combined with palm or safflower-seed oil, the results support that casein with safflower-seed oil may be effective in attenuating hyperuricaemia-associated renal damage, while soya protein with safflower-seed oil may be beneficial in lowering serum UA and TAG.
改善尿酸（UA）对肾脏损害的不良影响的饮食值得关注。研究了酪蛋白或大豆蛋白与棕榈或红花籽油结合对高尿酸血症大鼠的各种血清参数和肾脏组织学的影响。给雄性 Wistar 大鼠喂食氧嗪酸钾和 UA 以诱导高尿酸血症，并给它们喂食酪蛋白或大豆蛋白加棕榈或红花籽油补充饮食。正常大鼠和给予别嘌醇治疗（饮用水中 150mg/L）的高尿酸血症大鼠喂食酪蛋白加玉米油补充饮食。8 周后，别嘌醇治疗和大豆蛋白加红花籽油补充饮食显著降低了高尿酸血症大鼠的血清 UA（单因素方差分析；P<0.05）。此外，大豆蛋白和酪蛋白分别减轻了高尿酸血症引起的血清白蛋白和胰岛素降低（双因素方差分析；P<0.05）。红花籽油显著降低了血清 TAG 和 UA，而棕榈油显著增加了血清胆固醇、TAG、血尿素氮和肌酐。然而，大豆蛋白显著降低了肾脏 NO 和硝基酪氨酸，而棕榈油显著降低了肾脏硝基酪氨酸、TNF-α 和干扰素-γ，并增加了肾脏转化生长因子-β。酪蛋白加红花籽油显著减轻了肾小管间质性肾炎、结晶和纤维化。与酪蛋白与棕榈或红花籽油相比，结果表明，酪蛋白加红花籽油可能有效减轻与高尿酸血症相关的肾脏损害，而大豆蛋白加红花籽油可能有益于降低血清 UA 和 TAG。
