药物靶点消失之谜

The case of the disappearing drug target.

机构信息

Howard Hughes Medical Institute, Department of Chemistry and Biochemistry, University of Colorado, Boulder, CO 80309, USA.

出版信息

Mol Cell. 2010 Feb 26;37(4):455-6. doi: 10.1016/j.molcel.2010.02.010.

DOI:10.1016/j.molcel.2010.02.010

PMID:20188664

Abstract

In this issue of Molecular Cell, Hoshi et al. (2010) report two examples in which small molecule inhibitors are rendered ineffective when their kinase targets are involved in protein-protein interactions, highlighting differences between in vivo and in vitro inhibition kinetics.

摘要

在本期《分子细胞》中，Hoshi 等人（2010）报告了两个小分子抑制剂在其激酶靶标参与蛋白质-蛋白质相互作用时失效的例子，突出了体内和体外抑制动力学之间的差异。