局部 cAMP 信号在疾病中的作用一览。
Local cAMP signaling in disease at a glance.
机构信息
Department of Neuroscience, Physiology and Pharmacology, University College London, Gower Street, London WC1E 6BT, UK.
出版信息
J Cell Sci. 2013 Oct 15;126(Pt 20):4537-43. doi: 10.1242/jcs.133751.
Abstract
The second messenger cyclic AMP (cAMP) operates in discrete subcellular regions within which proteins that synthesize, break down or respond to the second messenger are precisely organized. A burgeoning knowledge of compartmentalized cAMP signaling is revealing how the local control of signaling enzyme activity impacts upon disease. The aim of this Cell Science at a Glance article and the accompanying poster is to highlight how misregulation of local cyclic AMP signaling can have pathophysiological consequences. We first introduce the core molecular machinery for cAMP signaling, which includes the cAMP-dependent protein kinase (PKA), and then consider the role of A-kinase anchoring proteins (AKAPs) in coordinating different cAMP-responsive proteins. The latter sections illustrate the emerging role of local cAMP signaling in four disease areas: cataracts, cancer, diabetes and cardiovascular diseases.
摘要
第二信使环腺苷酸（cAMP）在离散的细胞区室中发挥作用，在这些区室中，合成、分解或响应第二信使的蛋白质被精确地组织在一起。对区室化 cAMP 信号转导的不断增长的认识揭示了信号酶活性的局部控制如何影响疾病。本文和配套海报的目的是强调局部 cAMP 信号转导的失调如何产生病理生理后果。我们首先介绍 cAMP 信号转导的核心分子机制，包括 cAMP 依赖性蛋白激酶（PKA），然后考虑 A-激酶锚定蛋白（AKAPs）在协调不同的 cAMP 反应蛋白中的作用。后几节说明了局部 cAMP 信号转导在四个疾病领域的新兴作用：白内障、癌症、糖尿病和心血管疾病。
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