Div. of Applied Physiology, Dept. of Exercise Science, Arnold School of Public Health, University of South Carolina, Columbia, SC 29208, USA.
Int J Sport Nutr Exerc Metab. 2010 Feb;20(1):56-62. doi: 10.1123/ijsnem.20.1.56.
Quercetin, a natural polyphenolic flavonoid substance present in a variety of food plants, has been shown in vitro and in animal studies to have widespread health and performance benefits resulting from a combination of biological properties, including antioxidant and anti-inflammatory activity, as well as the ability to increase mitochondrial biogenesis. Little is known about these effects in humans, however, especially with respect to exercise performance. The authors determined whether quercetin ingestion would enhance maximal aerobic capacity and delay fatigue during prolonged exercise in healthy but untrained participants. Twelve volunteers were randomly assigned to 1 of 2 treatments: (a) 500 mg of quercetin twice daily dissolved in vitamin-enriched Tang or (b) a nondistinguishable placebo (Tang). Baseline VO2max and bike-ride times to fatigue were established. Treatments were administered for a period of 7 days using a randomized, double-blind, placebo-controlled, crossover study design. After treatment both VO2max and ride time to fatigue were determined. Seven days of quercetin feedings were associated with a modest increase in VO2max (3.9% vs. placebo; p < .05) along with a substantial (13.2%) increase in ride time to fatigue (p < .05). These data suggest that as little as 7 days of quercetin supplementation can increase endurance without exercise training in untrained participants. These benefits of quercetin may have important implications for enhancement of athletic and military performance. This apparent increase in fitness without exercise training may have implications beyond that of performance enhancement to health promotion and disease prevention.
槲皮素是一种天然多酚类黄酮物质，存在于多种植物性食物中，已在体外和动物研究中显示出广泛的健康和性能益处，这是由于其多种生物学特性的结合，包括抗氧化和抗炎活性，以及增加线粒体生物发生的能力。然而，人们对这些在人体中的作用知之甚少，特别是在运动表现方面。作者确定了槲皮素的摄入是否会在健康但未经训练的参与者中增强最大有氧能力并延迟长时间运动中的疲劳。12 名志愿者被随机分配到以下 2 种治疗组之一：（a）每天两次服用 500 毫克槲皮素，溶于富含维生素的 Tang 中，或（b）服用不可分辨的安慰剂（Tang）。确定了基线最大摄氧量和疲劳时的自行车骑行时间。使用随机、双盲、安慰剂对照、交叉研究设计进行了为期 7 天的治疗。治疗后，确定了最大摄氧量和疲劳时的骑行时间。7 天的槲皮素喂养与最大摄氧量适度增加（与安慰剂相比增加 3.9%；p <.05）以及疲劳时骑行时间显著增加（增加 13.2%；p <.05）相关。这些数据表明，在未经训练的参与者中，即使进行 7 天的槲皮素补充也可以在不进行运动训练的情况下提高耐力。槲皮素的这些益处可能对提高运动员和军人的表现具有重要意义。这种无需运动训练即可提高健康水平的明显效果可能不仅限于提高表现，还可能对促进健康和预防疾病产生影响。
