空气污染对血压、血脂和血糖的影响：基于人群的研究方法。
Effect of air pollution on blood pressure, blood lipids, and blood sugar: a population-based approach.
机构信息
Institute of Occupational Medicine and Industrial Hygiene, College of Public Health, National Taiwan University, Taipei, Taiwan.
出版信息
J Occup Environ Med. 2010 Mar;52(3):258-62. doi: 10.1097/JOM.0b013e3181ceff7a.
OBJECTIVE
To investigate changes in blood pressure, lipids, and sugar associated with changes in exposure to ambient air pollution.
METHODS
We conducted secondary analyses of blood pressure and biochemistry markers from Taiwanese Survey on Prevalence of Hyperglycemia, Hyperlipidemia, and Hypertension and air pollution monitoring data in 2002 by applying generalized additive models.
RESULTS
We observed increased particulate matter with aerodynamic diameters <10 microm was associated with elevated systolic blood pressure (an interquartile range, 34 microg/m, for 0.47 mmHg; 95% CI, -0.09 to 1.02), triglyceride, apolipoprotein B, hemoglobin A1c, and reduced high-density lipoprotein cholesterol. Elevated ozone was associated with increased diastolic blood pressure, apolipoprotein B, and hemoglobin A1c.
CONCLUSIONS
Alterations of atherosclerotic indicators are associated with particulate matter with aerodynamic diameters <10 microm and ozone changes. This might provide a link between air pollution and progression of atherosclerotic cardiovascular diseases.
目的
探讨与环境空气污染暴露变化相关的血压、血脂和血糖变化。
方法
我们通过广义加性模型对 2002 年台湾高血糖、高血脂和高血压患病率调查中的血压和生化标志物与空气污染监测数据进行了二次分析。
结果
我们发现，空气动力学直径 <10 微米的颗粒物与收缩压升高（四分位间距，34μg/m，升高 0.47mmHg；95%置信区间，-0.09 至 1.02）、甘油三酯、载脂蛋白 B、糖化血红蛋白和高密度脂蛋白胆固醇降低有关。臭氧升高与舒张压、载脂蛋白 B 和糖化血红蛋白升高有关。
结论
动脉粥样硬化指标的改变与空气动力学直径 <10 微米的颗粒物和臭氧变化有关。这可能为空气污染与动脉粥样硬化性心血管疾病的进展之间提供了联系。
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