Davies D J, Dowling J, Xipell J M
Pathology. 1977 Oct;9(4):281-8. doi: 10.3109/00313027709094448.
Nephropathy with proteinuria is an occasional complication of gold therapy for rheumatoid arthritis and is considered to be due to an immune hypersensitivity reaction. Three patients are described in whom the structural changes typical of gold nephropathy were demonstrated by electron microscopy of renal biopsies. There was early membranous glomerular nephropathy with multiple sub-epithelial deposits of immune complexes. In one case these were shown by immunofluorescence to contain IgG and complement. Proximal tubules contained characteristic dense granular intracytoplasmic gold inclusions, best demonstrated by electron microscopy of unstained sections.
蛋白尿性肾病是类风湿关节炎金疗法的一种偶发并发症，被认为是由免疫超敏反应所致。本文描述了3例患者，通过肾活检的电子显微镜检查证实了典型的金肾病结构改变。早期为膜性肾小球肾病，有多个免疫复合物的上皮下沉积物。在1例病例中，免疫荧光显示这些沉积物含有IgG和补体。近端小管含有特征性的致密颗粒状胞浆内金包涵体，在未染色切片的电子显微镜检查中显示最佳。
