[巴西帕拉州库亚巴-圣塔伦高速公路（BR-163）沿线受影响地区的虫媒病毒生态流行病学]

[Arbovirus eco-epidemiology in the area affected by the Cuiabá-Santarém Highway (BR-163), Pará State, Brazil].

作者信息

Nunes Marcio Roberto Teixeira, Barbosa Taciana Fernandes Souza, Casseb Lívia Medeiros Neves, Nunes Neto Joaquim Pinto, Segura Nazaré de Oliveira, Monteiro Hamilton Antônio de Oliveira, Pinto Eliana Vieira, Casseb Samir Mansour, Chiang Jannifer de Oliveira, Martins Lívia Caricio, Medeiros Daniele Barbosa de Almeida, Vasconcelos Pedro Fernando da Costa

机构信息

Seção de Arbovirologia e Febres Hemorrágicas, Instituto Evandro Chagas, Ananindeua, PA, Brazil.

出版信息

Cad Saude Publica. 2009 Dec;25(12):2583-602. doi: 10.1590/s0102-311x2009001200006.

DOI:10.1590/s0102-311x2009001200006

PMID:20191150

Abstract

The current study describes the eco-epidemiological aspects of arbovirus diseases in the municipalities (counties) of Novo Progresso and Trairão, Para State, Brazil, in the area affected by highway BR-163. Hemagglutination inhibition (HI) antibodies to different arboviruses were detected, with monotypic reactions to MAYV and OROV, two important arboviruses associated with epidemics in the Amazon. IgM antibodies to OROV and MAYV were found in human sera, suggesting recent infections by these viruses. Two DENV-3 strains were isolated from febrile patients in Novo Progresso and identified as genotype III strains. In general, the data suggest that the area displays ideal conditions for maintenance and circulation of arboviruses, plus a population with low immunization levels. Dynamic surveillance of local immigrants and wild animals is thus important, focusing on antibody prevalence and isolation of arboviruses, thereby allowing effective control of infections by these viral agents in the resident population along highway BR-163 in Pará State.

摘要

本研究描述了巴西帕拉州新普罗格雷索市和特拉朗市（县）受BR-163高速公路影响地区虫媒病毒疾病的生态流行病学情况。检测了针对不同虫媒病毒的血凝抑制（HI）抗体，发现对马亚罗病毒（MAYV）和奥罗普切病毒（OROV）呈单型反应，这两种重要的虫媒病毒与亚马逊地区的疫情有关。在人类血清中发现了针对OROV和MAYV的IgM抗体，表明这些病毒近期感染情况。从新普罗格雷索的发热患者中分离出两株登革热病毒3型（DENV-3）毒株，并鉴定为基因型III毒株。总体而言，数据表明该地区具备虫媒病毒维持和传播的理想条件，而且人群免疫水平较低。因此，对当地移民和野生动物进行动态监测很重要，重点是抗体流行情况和虫媒病毒的分离，从而有效控制帕拉州BR-163高速公路沿线常住人口中这些病毒病原体的感染。