镍催化室温下高官能化有机锌试剂与硫甲基化 N-杂环的交叉偶联反应。

Room temperature cross-coupling of highly functionalized organozinc reagents with thiomethylated N-heterocycles by nickel catalysis.

机构信息

Department Chemie, Ludwig-Maximilians-University, Butenandtstr. 5-13, Munich, Germany.

出版信息

J Org Chem. 2010 Mar 19;75(6):2131-3. doi: 10.1021/jo1001615.

PMID:20192173

Abstract

A variety of thiomethyl-substituted N-heterocycles such as pyridines, isoquinolines, pyrimidines, pyrazines, pyridazines, quinazolines, triazines, benzothiazoles, or benzoxazoles undergo smooth Ni-catalyzed cross-coupling reactions with functionalized aryl-, heteroaryl-, alkyl-, and benzylic zinc reagents using an inexpensive Ni(acac)(2)/DPE-Phos catalytic system at 25 degrees C.

摘要

各种噻甲基取代的 N-杂环化合物，如吡啶、异喹啉、嘧啶、吡嗪、哒嗪、喹唑啉、三嗪、苯并噻唑或苯并恶唑，在 25 摄氏度下，使用廉价的 Ni(acac)(2)/DPE-Phos 催化体系，与功能化的芳基、杂芳基、烷基和苄基锌试剂进行顺利的 Ni 催化交叉偶联反应。