Ga(III)-催化的环化异构化方法合成 (+/-)-icetexone 和 (+/-)-epi-icetexone。
Ga(III)-catalyzed cycloisomerization approach to (+/-)-icetexone and (+/-)-epi-icetexone.
机构信息
Department of Chemistry, University of California, Berkeley, California 94720, USA.
出版信息
Org Lett. 2010 Apr 2;12(7):1428-31. doi: 10.1021/ol902959v.
Abstract
A Ga(III)-catalyzed cycloisomerization reaction provides expedient access to a benzannulated cycloheptadiene bearing a cyano group, which has been applied to the syntheses of several icetexane diterpenoids including icetexone and epi-icetexone. Key to the synthesis is a novel in situ generated diazene rearrangement.
摘要
一种 Ga(III)催化的环化异构化反应为带有氰基的苯并环庚二烯的合成提供了一种简便的方法，该化合物已被应用于几种冰桐二萜类化合物的合成，包括冰桐酮和表冰桐酮。该合成的关键是一种新的原位生成的重氮烯重排。
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