Simmons Eric M, Sarpong Richmond
Department of Chemistry, University of California, Berkeley, 94720, USA.
Org Lett. 2006 Jun 22;8(13):2883-6. doi: 10.1021/ol061037c.
[reaction: see text] A general approach to the tricyclic core of the icetexane natural products via the cycloisomerization of alkynyl indenes using GaCl(3) is presented. This strategy provides an efficient synthesis of the natural product salviasperanol and sets the stage for access to other members of this family of diterpenoids.
[反应：见正文] 本文介绍了一种通过使用三氯化镓使炔基茚进行环异构化来构建冰叶烷天然产物三环核心的通用方法。该策略为天然产物丹参螺缩酮醇提供了一种高效合成方法，并为获取该二萜类化合物家族的其他成员奠定了基础。
