炎症性肠病。
Inflammatory bowel disease.
机构信息
Department of Medicine II, Medical University Innsbruck, Austria.
出版信息
Annu Rev Immunol. 2010;28:573-621. doi: 10.1146/annurev-immunol-030409-101225.
Abstract
Insights into inflammatory bowel disease (IBD) are advancing rapidly owing to immunologic investigations of a plethora of animal models of intestinal inflammation, ground-breaking advances in the interrogation of diseases that are inherited as complex genetic traits, and the development of culture-independent methods to define the composition of the intestinal microbiota. These advances are bringing a deeper understanding to the genetically determined interplay between the commensal microbiota, intestinal epithelial cells, and the immune system and the manner in which this interplay might be modified by relevant environmental factors in the pathogenesis of IBD. This review examines these interactions and, where possible, potential lessons from IBD-directed, biologic therapies that may allow for elucidation of pathways that are central to disease pathogenesis in humans.
摘要
由于对大量肠道炎症动物模型的免疫学研究、对作为复杂遗传特征遗传疾病的突破性研究，以及对定义肠道微生物组组成的非培养方法的发展，人们对炎症性肠病（IBD）的认识正在迅速深入。这些进展使人们对共生微生物群、肠上皮细胞和免疫系统之间由遗传决定的相互作用，以及这种相互作用如何被 IBD 发病机制中的相关环境因素改变有了更深入的了解。这篇综述检查了这些相互作用，并在可能的情况下，从针对 IBD 的生物治疗中吸取了一些教训，这些治疗可能有助于阐明对人类疾病发病机制至关重要的途径。
相似文献
1
Inflammatory bowel disease.炎症性肠病。
Annu Rev Immunol. 2010;28:573-621. doi: 10.1146/annurev-immunol-030409-101225.
2
Inflammatory bowel disease: recent advances on genetics and innate immunity.炎症性肠病：遗传学与固有免疫的最新进展
Ann Gastroenterol. 2011;24(3):164-172.
3
Inflammation in the intestinal tract: pathogenesis and treatment.肠道炎症：发病机制与治疗。
Dig Dis. 2009;27(4):455-64. doi: 10.1159/000235851. Epub 2009 Nov 4.
4
Intestinal microbiota in inflammatory bowel disease: friend of foe?炎症性肠病中的肠道微生物群：敌是友？
World J Gastroenterol. 2011 Feb 7;17(5):557-66. doi: 10.3748/wjg.v17.i5.557.
5
The Innate and Adaptive Immune System as Targets for Biologic Therapies in Inflammatory Bowel Disease.先天免疫系统和适应性免疫系统作为炎症性肠病生物治疗的靶点。
Int J Mol Sci. 2017 Sep 21;18(10):2020. doi: 10.3390/ijms18102020.
6
7
Interactions between intestinal microbiota and innate immune system in pediatric inflammatory bowel disease.小儿炎症性肠病中肠道微生物群与固有免疫系统的相互作用。
J Clin Gastroenterol. 2012 Oct;46 Suppl:S64-6. doi: 10.1097/MCG.0b013e31826a857f.
8
The interplay between microbes and the immune response in inflammatory bowel disease.微生物与炎症性肠病中免疫应答的相互作用。
J Physiol. 2018 Sep;596(17):3869-3882. doi: 10.1113/JP275396. Epub 2018 Jul 17.
9
Unravelling the pathogenesis of inflammatory bowel disease.揭示炎症性肠病的发病机制。
Nature. 2007 Jul 26;448(7152):427-34. doi: 10.1038/nature06005.
10
Genetics and pathogenesis of inflammatory bowel disease.炎症性肠病的遗传学与发病机制。
Nature. 2011 Jun 15;474(7351):307-17. doi: 10.1038/nature10209.
引用本文的文献
1
Interaction between gut virome and microbiota on inflammatory bowel disease.肠道病毒组与微生物群在炎症性肠病中的相互作用。
World J Methodol. 2025 Sep 20;15(3):100332. doi: 10.5662/wjm.v15.i3.100332.
2
Metabolomics and proteomics reveal blocking argininosuccinate synthetase 1 alleviates colitis in mice.代谢组学和蛋白质组学研究表明，抑制精氨酸琥珀酸合成酶1可缓解小鼠结肠炎。
Nat Commun. 2025 Jul 30;16(1):6983. doi: 10.1038/s41467-025-62217-8.
3
Exosome-like nanovesicles from Peucedanum Japonicum directly regulate inflammatory cytokines via small RNAs.日本前胡来源的外泌体样纳米囊泡通过小RNA直接调节炎性细胞因子。
Sci Rep. 2025 Jul 28;15(1):27424. doi: 10.1038/s41598-025-12175-4.
4
Endoscopic healing in pediatric IBD perpetuates a persistent signature defined by Th17 cells with molecular and microbial drivers of disease.小儿炎症性肠病的内镜愈合使由Th17细胞定义的持续特征持续存在，这些细胞具有疾病的分子和微生物驱动因素。
Cell Rep Med. 2025 Jul 15;6(7):102236. doi: 10.1016/j.xcrm.2025.102236.
5
Pathogenesis guided application of nanozymes in the treatment of inflammatory bowel disease.基于发病机制指导的纳米酶在炎症性肠病治疗中的应用
Mater Today Bio. 2025 Jun 21;33:102008. doi: 10.1016/j.mtbio.2025.102008. eCollection 2025 Aug.
6
Phenolic Profiling and Bioactive Properties of Extract in Alleviating Acute and Sub-Chronic Colitis.提取物的酚类成分分析及其在缓解急性和亚慢性结肠炎方面的生物活性特性
Int J Mol Sci. 2025 Jun 13;26(12):5692. doi: 10.3390/ijms26125692.
7
JAK Inhibitor and Crohn's Disease.JAK抑制剂与克罗恩病
Biomedicines. 2025 May 29;13(6):1325. doi: 10.3390/biomedicines13061325.
8
The impact of artificial intelligence on the endoscopic assessment of inflammatory bowel disease-related neoplasia.人工智能对炎症性肠病相关肿瘤内镜评估的影响。
Therap Adv Gastroenterol. 2025 Jun 23;18:17562848251348574. doi: 10.1177/17562848251348574. eCollection 2025.
9
Immunological pathogenesis of inflammatory bowel disease: focus on tissue resident memory T cells.炎症性肠病的免疫发病机制：聚焦于组织驻留记忆T细胞。
Front Immunol. 2025 Jun 3;16:1591584. doi: 10.3389/fimmu.2025.1591584. eCollection 2025.
10
Gallic acid serves as an effective therapeutic agent of inflammatory bowel disease: Pharmacological impacts on tight junction-dependent intestinal permeability and its related intracellular signaling.没食子酸是炎症性肠病的有效治疗剂：对紧密连接依赖性肠道通透性及其相关细胞内信号传导的药理学影响
Curr Res Pharmacol Drug Discov. 2025 May 17;8:100223. doi: 10.1016/j.crphar.2025.100223. eCollection 2025.
本文引用的文献
1
NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation.NOD2 刺激诱导树突状细胞自噬，影响细菌处理和抗原呈递。
Nat Med. 2010 Jan;16(1):90-7. doi: 10.1038/nm.2069. Epub 2009 Dec 6.
2
Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry.Nod1 和 Nod2 通过将 ATG16L1 招募到细菌进入部位的质膜上来指导自噬。
Nat Immunol. 2010 Jan;11(1):55-62. doi: 10.1038/ni.1823. Epub 2009 Nov 8.
3
Inflammatory bowel disease and mutations affecting the interleukin-10 receptor.炎症性肠病与影响白细胞介素-10受体的突变
N Engl J Med. 2009 Nov 19;361(21):2033-45. doi: 10.1056/NEJMoa0907206. Epub 2009 Nov 4.
4
A dominant, coordinated T regulatory cell-IgA response to the intestinal microbiota.对肠道微生物群的显性、协调性调节性T细胞-IgA反应。
Proc Natl Acad Sci U S A. 2009 Nov 17;106(46):19256-61. doi: 10.1073/pnas.0812681106. Epub 2009 Nov 4.
5
T cell-intrinsic role of Nod2 in promoting type 1 immunity to Toxoplasma gondii.Nod2在促进对刚地弓形虫1型免疫中的T细胞内在作用。
Nat Immunol. 2009 Dec;10(12):1267-74. doi: 10.1038/ni.1816. Epub 2009 Nov 1.
6
Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43.肠道微生物群和趋化因子受体GPR43对炎症反应的调节
Nature. 2009 Oct 29;461(7268):1282-6. doi: 10.1038/nature08530.
7
Endoplasmic reticulum stress and intestinal inflammation.内质网应激与肠道炎症。
Mucosal Immunol. 2010 Jan;3(1):11-6. doi: 10.1038/mi.2009.122. Epub 2009 Oct 28.
8
Induction of intestinal Th17 cells by segmented filamentous bacteria.分节丝状菌诱导肠道Th17细胞
Cell. 2009 Oct 30;139(3):485-98. doi: 10.1016/j.cell.2009.09.033.
9
The key role of segmented filamentous bacteria in the coordinated maturation of gut helper T cell responses.分段丝状细菌在肠道辅助性T细胞反应协同成熟中的关键作用。
Immunity. 2009 Oct 16;31(4):677-89. doi: 10.1016/j.immuni.2009.08.020.
10
Nod2 is required for the regulation of commensal microbiota in the intestine.Nod2是调节肠道共生微生物群所必需的。
Proc Natl Acad Sci U S A. 2009 Sep 15;106(37):15813-8. doi: 10.1073/pnas.0907722106. Epub 2009 Sep 1.
Zotero 插件