Attikon University General Hospital, 1 Rimini Str., 12462 Athens, Greece.
Eur J Clin Invest. 2010 Apr;40(4):288-93. doi: 10.1111/j.1365-2362.2010.02257.x.
Osteopontin (OPN) is a glycoprotein, which may play a major role in the regulation of biological phenomena. Increased levels of OPN have been linked to the presence and to the severity of atherosclerosis. This study was undertaken to assess the prognostic significance of plasma OPN levels in patients with stable ischaemic heart disease (IHD).
In 101 patients with stable IHD and angiographically documented significant coronary artery stenosis, plasma OPN levels were measured at baseline (time of coronary arteriography). Patients were prospectively followed for a median time of 3 years (minimum 2.25, maximum 3.9 years). The primary study endpoint was the composite of cardiovascular death, non-fatal myocardial infarction, need for revascularization and hospitalization for cardiovascular reasons.
Baseline lnOPN levels were directly related to age (r = 0.27, P < 0.001) and inversely to left ventricular ejection fraction (r = -0.32, P < 0.01). Left ventricular ejection fraction was an independent predictor of plasma OPN levels after adjustment for age and gender (beta = -0.013, P = 0.02). Median OPN value was 55 ng mL(-1). In the univariate Cox-regression analysis, OPN levels > 55 ng mL(-1) (n = 50) were significantly related to adverse cardiac outcome (HR = 2.40, 95% CI: 1.11-5.23, P = 0.027). In multivariate model, OPN levels > 55 ng mL(-1) remained statistically significant independent predictor of adverse outcome after adjustment for age, gender, left ventricular ejection fraction and the number of diseased coronary arteries (HR = 2.88, 95% CI: 1.09-7.58, P = 0.032).
OPN may provide significant prognostic information independent of other traditional prognostic markers in patients with stable IHD.
骨桥蛋白（OPN）是一种糖蛋白，可能在调节生物现象中发挥主要作用。OPN 水平升高与动脉粥样硬化的存在和严重程度有关。本研究旨在评估稳定型缺血性心脏病（IHD）患者血浆 OPN 水平的预后意义。
在 101 例经冠状动脉造影证实有严重冠状动脉狭窄的稳定型 IHD 患者中，在基线时（冠状动脉造影时）测量血浆 OPN 水平。前瞻性随访患者中位时间为 3 年（最短 2.25 年，最长 3.9 年）。主要研究终点是心血管死亡、非致死性心肌梗死、血运重建和因心血管原因住院的复合终点。
基线 lnOPN 水平与年龄呈直接相关（r = 0.27，P < 0.001），与左室射血分数呈负相关（r = -0.32，P < 0.01）。在校正年龄和性别后，左室射血分数是血浆 OPN 水平的独立预测因子（β = -0.013，P = 0.02）。中位数 OPN 值为 55ng/ml。在单变量 Cox 回归分析中，OPN 水平>55ng/ml（n = 50）与不良心脏结局显著相关（HR = 2.40，95%CI：1.11-5.23，P = 0.027）。在多变量模型中，校正年龄、性别、左室射血分数和病变冠状动脉数量后，OPN 水平>55ng/ml 仍然是不良结局的独立预测因子（HR = 2.88，95%CI：1.09-7.58，P = 0.032）。
OPN 可能为稳定型 IHD 患者提供独立于其他传统预后标志物的重要预后信息。
