Zeng Yao-chi, Hu Min-yu, Qu Shu-lin, Zhou Guang-yu
Nutrition Department, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen 518033, China.
Zhonghua Yu Fang Yi Xue Za Zhi. 2009 Dec;43(12):1064-8.
To study the effect of lycopene on red blood cell and the level of blood lipid.
According to the level of serum total cholesterol and weight, forty-eight adult male SD rats were divided randomly into six groups: normal control (group A), fed by normal feed; hyperlipidemia group (group B): fed by high fat diet; positive control group (group C): fed by high fat diet plus 10 mg * kg(-1) * d(-1) fluvastatin sodium; lycopene groups: fed by high fat diet plus 11 (group D), 22 (group E), 44 mg * kg(-1) * d(-1) (group F) lycopene through gavage, respectively. For all six groups, the level of serum total cholesterol (TC) and total triglyceride (TG) were measured at the end of 0, 1, 3 weeks of the study by taking samples from tail vein. At the end of the experiment, RBC and HGB were measured.
After the rats were fed with high-fat feed for a week, models of hyperlipidemia rats were established. At the end of 3 weeks, TC of group A, B, C, D, E and F were (1.31 +/- 0.05), (19.40 +/- 0.54), (4.66 +/- 0.07), (7.18 +/- 0.06), (5.30 +/- 0.28), (4.49 +/- 0.23) mmol/L (F = 4395.72, P = 0.00), respectively;and TG were (0.42 +/- 0.01), (2.29 +/- 0.42), (0.69 +/- 0.03), (1.10 +/- 0.05), (0.63 +/- 0.02), (0.62 +/- 0.04) mmol/L (F = 127.26, P = 0.00), respectively; HGB were (143.13 +/- 6.33), (112.63 +/- 2.56), (124.75 +/- 3.62), (124.63 +/- 7.78), (132.38 +/- 6.41), (142.13 +/- 5.54) g/L (F = 34.14, P = 0.00), respectively; RBC were (6.75 +/- 0.60) x 10(12)/L, (5.08 +/- 0.75) x 10(12)/L, (7.14 +/- 0.82) x 10(12)/L, (5.94 +/- 1.09) x 10(12)/L, (6.18 +/- 0.36) x 10(12)/L and (7.31 +/- 0.58) x 10(12)/L (F = 10.35, P = 0.00), respectively.
Lycopene have some protective effects on red blood cells of the hyperlipidemic rats by regulating the blood lipid and antioxidant.
研究番茄红素对红细胞及血脂水平的影响。
根据血清总胆固醇水平和体重，将48只成年雄性SD大鼠随机分为6组：正常对照组（A组），喂以正常饲料；高脂血症组（B组）：喂以高脂饲料；阳性对照组（C组）：喂以高脂饲料加10 mg·kg⁻¹·d⁻¹氟伐他汀钠；番茄红素组：分别通过灌胃给予高脂饲料加11（D组）、22（E组）、44 mg·kg⁻¹·d⁻¹（F组）番茄红素。6组大鼠均在实验第0、1、3周结束时经尾静脉采血，检测血清总胆固醇（TC）和总甘油三酯（TG）水平。实验结束时，检测红细胞（RBC）和血红蛋白（HGB）。
大鼠喂饲高脂饲料1周后，高脂血症大鼠模型建立成功。3周结束时，A、B、C、D、E、F组的TC分别为（1.31±0.05）、（19.40±0.54）、（4.66±0.07）、（7.18±0.06）、（5.30±0.28）、（4.49±0.23）mmol/L（F = 4395.72，P = 0.00）；TG分别为（0.42±0.01）、（2.29±0.42）、（0.69±0.03）、（1.10±0.05）、（0.63±0.02）、（0.62±0.04）mmol/L（F = 127.26，P = 0.00）；HGB分别为（143.13±6.33）、（112.63±2.56）、（124.75±3.62）、（124.63±7.78）、（132.38±6.41）、（142.13±5.54）g/L（F = 34.14，P = 0.00）；RBC分别为（6.75±0.60）×10¹²/L、（5.08±0.75）×10¹²/L、（7.14±0.82）×10¹²/L、（5.94±1.09）×10¹²/L、（6.18±0.36）×10¹²/L和（7.31±0.58）×10¹²/L（F = 10.35，P = 0.00）。
番茄红素通过调节血脂和抗氧化对高脂血症大鼠的红细胞具有一定的保护作用。
