Orbach Hedi, Agmon-Levin Nancy, Zandman-Goddard Gisele
Department of Medicine B, Wolfson Medical Center, Holon, Israel.
Discov Med. 2010 Feb;9(45):90-7.
Infectious agents contribute to the environmental factors involved in the development of autoimmune diseases possibly through molecular mimicry mechanisms. Hence, it is feasible that vaccinations may also contribute to the mosaic of autoimmunity. Evidence for the association of vaccinations and the development of these diseases is presented in this review. Infrequently reported post-vaccination autoimmune diseases include systemic lupus erythematosus, rheumatoid arthritis, inflammatory myopathies, multiple sclerosis, Guillain-Barré syndrome, and vasculitis. In addition, we will discuss macrophagic myofasciitis, aluminum containing vaccines, and the recent evidence for autoimmunity following the use of human papillomavirus vaccine.
感染因子可能通过分子模拟机制促成自身免疫性疾病发生发展过程中的环境因素。因此，疫苗接种也可能促成自身免疫性疾病的综合情况，这是可行的。本综述展示了疫苗接种与这些疾病发生之间关联的证据。疫苗接种后较少报道的自身免疫性疾病包括系统性红斑狼疮、类风湿性关节炎、炎性肌病、多发性硬化症、吉兰-巴雷综合征和血管炎。此外，我们还将讨论巨噬细胞性肌筋膜炎、含铝疫苗以及使用人乳头瘤病毒疫苗后自身免疫性的最新证据。
