How GABA generates depolarization.
作者信息
Spitzer Nicholas C
机构信息
Neurobiology Section, Kavli Institute for Brain and Mind, UCSD, La Jolla, CA 92093-0357, USA.
出版信息
J Physiol. 2010 Mar 1;588(Pt 5):757-8. doi: 10.1113/jphysiol.2009.183574.
Abstract
摘要
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J Physiol. 2010 Mar 1;588(Pt 5):757-8. doi: 10.1113/jphysiol.2009.183574.
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Energy substrate availability as a determinant of neuronal resting potential, GABA signaling and spontaneous network activity in the neonatal cortex in vitro.能量底物可用性作为体外新生皮质神经元静息电位、GABA 信号和自发网络活动的决定因素。
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2
Maternal oxytocin triggers a transient inhibitory switch in GABA signaling in the fetal brain during delivery.分娩过程中，母体催产素会引发胎儿大脑中γ-氨基丁酸（GABA）信号传导的短暂抑制性转换。
Science. 2006 Dec 15;314(5806):1788-92. doi: 10.1126/science.1133212.
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Sequential interplay of nicotinic and GABAergic signaling guides neuronal development.烟碱能信号与γ-氨基丁酸能信号的顺序相互作用引导神经元发育。
Science. 2006 Dec 8;314(5805):1610-3. doi: 10.1126/science.1134246.
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GABA regulates synaptic integration of newly generated neurons in the adult brain.γ-氨基丁酸（GABA）调节成体大脑中新生神经元的突触整合。
Nature. 2006 Feb 2;439(7076):589-93. doi: 10.1038/nature04404. Epub 2005 Dec 11.
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Depolarizing GABA acts on intrinsically bursting pyramidal neurons to drive giant depolarizing potentials in the immature hippocampus.去极化型γ-氨基丁酸作用于内在爆发式发放的锥体神经元，以驱动未成熟海马体中的巨大去极化电位。
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GABA-mediated giant depolarizing potentials as coincidence detectors for enhancing synaptic efficacy in the developing hippocampus.γ-氨基丁酸（GABA）介导的巨大去极化电位作为发育中海马体增强突触效能的巧合探测器。
Proc Natl Acad Sci U S A. 2004 Mar 16;101(11):3967-72. doi: 10.1073/pnas.0305974101. Epub 2004 Mar 8.
7
Developmental up-regulation of KCC2 in the absence of GABAergic and glutamatergic transmission.在缺乏γ-氨基丁酸能和谷氨酸能传递的情况下，KCC2的发育性上调。
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8
BDNF regulates spontaneous correlated activity at early developmental stages by increasing synaptogenesis and expression of the K+/Cl- co-transporter KCC2.脑源性神经营养因子通过增加突触形成和钾离子/氯离子协同转运体KCC2的表达，在发育早期调节自发关联活动。
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Two-photon chloride imaging in neurons of brain slices.脑片神经元中的双光子氯离子成像。
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10
Insulin-like growth factor 1 and a cytosolic tyrosine kinase activate chloride outward transport during maturation of hippocampal neurons.胰岛素样生长因子1和一种胞质酪氨酸激酶在海马神经元成熟过程中激活氯离子外向转运。
J Neurosci. 2001 Nov 1;21(21):8339-47. doi: 10.1523/JNEUROSCI.21-21-08339.2001.
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