Kleck J H, Benedict S H, Cook J S, Birdsall R L, Satyamurthy N
Radiation Safety Office, University of California, Los Angeles 90024.
Health Phys. 1991 May;60(5):657-60. doi: 10.1097/00004032-199105000-00003.
Fluorodeoxyglucose labeled with 18F (18F-FDG) is the most commonly used radiopharmaceutical in positron emission tomography (PET). Fluorine-18-labeled FDG is used as a diagnostic tool in PET studies to monitor the physiology of the brain, diagnose heart function and disease, and to image cancerous tumors. At the University of California, Los Angeles (UCLA), three cyclotrons produce [18F]-fluoride ion using 18O-enriched water targets. Fluorine-18, which has a half-life of 109.8 min, is produced using an 18O(p.n.)18F reaction and is chemically processed to yield 18F-FDG. This study presents data which demonstrate that during the radiochemical processes involved in the production of 18F-FDG, gaseous effluent containing 18F is released. Forty cyclotron production runs with average end of cyclotron bombardment activities of 15.9 +/- 1.88 GBq (430 +/- 50.8 mCi) and end of radiochemical synthesis activities of 5.40 +/- 1.27 GBq (146 +/- 34.3 mCi) yield 18F gaseous effluent releases ranging from 0 to 2560 MBq (0 to 69.2 mCi) with a mean of 437 MBq (11.8 mCi). Temporal correlation of the 18F gaseous releases during 18F-FDG radiochemical production has tied the 18F release to the addition of the glucose precursor (mannotriflate) and ethyl ether in the radiochemical processing. The results are presented in terms of activities released and dilution factors required from the release stack point to maintain controlled (occupational) and uncontrolled (public) area limits in accordance with the recommendations of the International Commission on Radiological Protection and the regulatory requirements of the federal government.
用18F标记的氟代脱氧葡萄糖（18F-FDG）是正电子发射断层扫描（PET）中最常用的放射性药物。氟-18标记的FDG在PET研究中用作诊断工具，以监测大脑生理功能、诊断心脏功能和疾病以及对癌性肿瘤进行成像。在加利福尼亚大学洛杉矶分校（UCLA），三台回旋加速器使用富含18O的水靶产生[18F]氟离子。半衰期为109.8分钟的氟-18通过18O（p，n）18F反应产生，并经过化学处理以生成18F-FDG。本研究提供的数据表明，在18F-FDG生产过程中的放射化学过程中，会释放出含有18F的气态流出物。四十次回旋加速器生产运行，回旋加速器轰击活动结束时的平均活度为15.9±1.88 GBq（430±50.8 mCi），放射化学合成活动结束时的平均活度为5.40±1.27 GBq（146±34.3 mCi），产生的18F气态流出物释放量范围为0至2560 MBq（0至69.2 mCi），平均为437 MBq（11.8 mCi）。18F-FDG放射化学生产过程中18F气态释放的时间相关性已将18F释放与放射化学处理中葡萄糖前体（甘露三氟甲磺酸酯）和乙醚的添加联系起来。结果以释放的活度和从释放烟囱点到维持受控（职业）和不受控（公众）区域限值所需的稀释因子表示，这是根据国际放射防护委员会的建议和联邦政府的监管要求得出的。
