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[18F]fluoride from a small cyclotron for the routine synthesis of [18F]2-fluoro-2-deoxy-D-glucose.

作者信息

Dejesus O T, Martin J A, Yasillo N J, Gatley S J, Cooper M D

出版信息

Int J Rad Appl Instrum A. 1986;37(5):397-401. doi: 10.1016/0883-2889(86)90095-x.

DOI:10.1016/0883-2889(86)90095-x
PMID:3019942
Abstract

[18F]Fluoride was produced via the 18O (p, n) 18F reaction using a low volume stainless steel 18O-water target in a small cyclotron. The average 18F production rate for 60 runs was about 720 microCi/microA-min. A typical bombardment time of 20 min produced 120 mCi of 18F-fluoride. [18F]2-Fluoro-2-deoxy-D-glucose ([18F]2FDG) was prepared using the procedure developed by Tewson [J. Nucl. Med. 24, 718 (1983)] involving a protected cyclic sulfate glucose derivative as precursor. The routine synthesis and quality testing of [18F]2FDG required 1 h and, typically, yields of 30-35 mCi of greater than 95% HPLC-pure product were obtained.

摘要

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