计算机控制的放射化学合成：用于放射化学制品自动化生产的化学过程控制单元。

Computer-controlled radiochemical synthesis: a chemistry process control unit for the automated production of radiochemicals.

作者信息

Padgett H C, Schmidt D G, Luxen A, Bida G T, Satyamurthy N, Barrio J R

机构信息

University of California, Department of Radiology, Los Angeles 90024.

出版信息

Int J Rad Appl Instrum A. 1989;40(5):433-45. doi: 10.1016/0883-2889(89)90213-x.

DOI:10.1016/0883-2889(89)90213-x

PMID:2548977

Abstract

A computer-controlled general purpose chemistry process control unit (CPCU) suitable for the automated production of radiochemicals has been developed. This valve-and-tubing synthesis system can be user programmed to accommodate a variety of chemical processes. In a practical demonstration of its utility, the CPCU has been configured and programmed to synthesize 2-deoxy-2-[18F]fluoro-D-glucose (2-[18F]FDG) using aqueous [18F]fluoride ion. Using this instrument, the yield of 2-[18F]FDG from [18F]fluoride ion is 54.9% (+/- 11.2%, n = 125) corrected to EOB, after a synthesis time of 50-55 min. The average total activity produced (for runs of 5-10 microA) is 28.1 mCi/microA (+/- 5.03 mCi/microA). Thus, the amount of 2-[18F]FDG produced from a 10 microA for 1 h bombardment was 154.3 mCi (+/- 27.4 mCi). The unit has been similarly configured and programmed to synthesize 2-deoxy-2-[18F]fluoro-D-mannose (48% EOB), 3-(2'-[18F]fluoroethyl)spiperone (29% EOB), and [18F]fluoroacetate (66% EOB) from aqueous [18F]-fluoride ion, and 2-[18F]FDG from gaseous acetyl hypo[18F]fluorite (20% EOB).

摘要

已开发出一种适用于放射性药物自动化生产的计算机控制通用化学过程控制单元（CPCU）。这种阀门和管道合成系统可由用户编程，以适应各种化学过程。在其实用性的实际演示中，CPCU已被配置和编程，以使用[18F]氟离子水溶液合成2-脱氧-2-[18F]氟-D-葡萄糖（2-[18F]FDG）。使用该仪器，在50-55分钟的合成时间后，以EOB校正，[18F]氟离子生成2-[18F]FDG的产率为54.9%（±11.2%，n = 125）。产生的平均总活度（对于5-10微安的运行）为28.1毫居里/微安（±5.03毫居里/微安）。因此，10微安轰击1小时产生的2-[18F]FDG量为154.3毫居里（±27.4毫居里）。该单元已类似地配置和编程，以从[18F]氟离子水溶液中合成2-脱氧-2-[18F]氟-D-甘露糖（48% EOB）、3-(2'-[18F]氟乙基)螺哌隆（29% EOB）和[18F]氟乙酸盐（66% EOB），并从气态次[18F]氟乙酰合成2-[18F]FDG（20% EOB）。