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海绵来源真菌 Aspergillus versicolor 的生物活性代谢产物。

Bioactive metabolites from the sponge-derived fungus Aspergillus versicolor.

机构信息

College of Pharmacy, Pusan National University, Busan 609-735, Korea.

出版信息

Arch Pharm Res. 2010 Feb;33(2):231-5. doi: 10.1007/s12272-010-0207-4. Epub 2010 Feb 24.

Abstract

As part of an ongoing search for bioactive metabolites from the fungus Aspergillus versicolor derived from a marine sponge Petrosia sp., an aromatic polyketide derivative (1), two xanthones (2 and 3), and five anthraquinones (4-8) were isolated by bioactivity-guided fractionation. The gross structures were determined based on the NMR and MS spectroscopic data, and the absolute configurations were defined by comparison of optical rotation data with those of reported. Compounds 2, 4, 5, and 7 exhibited significant cytotoxicity against five human solid tumor cell lines (A-549, SK-OV-3, SK-MEL-2, XF-498, and HCT-15) with IC50 values in the range of 0.41-4.61 microg/mL. Compounds 4 and 7 exhibited antibacterial activity against several clinically isolated Gram-positive strains with MIC values of 0.78-6.25 microg/mL.

摘要

从海绵 Petrosia sp. 衍生的真菌 Aspergillus versicolor 中寻找生物活性代谢产物的过程中,通过活性导向分离得到了一种芳香聚酮衍生物(1)、两种黄烷酮(2 和 3)和五种蒽醌(4-8)。根据 NMR 和 MS 光谱数据确定了它们的总结构,并通过与文献报道的旋光数据比较确定了绝对构型。化合物 2、4、5 和 7 对五种人实体瘤细胞系(A-549、SK-OV-3、SK-MEL-2、XF-498 和 HCT-15)具有显著的细胞毒性,IC50 值在 0.41-4.61 μg/mL 范围内。化合物 4 和 7 对几种临床分离的革兰氏阳性菌株具有抗菌活性,MIC 值为 0.78-6.25 μg/mL。

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