• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

对源自海洋物种的天然产物作为抗病原菌来源的研究意义。

Significance of research on natural products from marine-derived species as a source against pathogenic bacteria.

作者信息

Wang Bin, Cai Jin, Huang Longtao, Chen Yonghao, Wang Ruoxi, Luo Mengyao, Yang Meng, Zhang Mohan, Chen Guangying, Huang Guolei, Zheng Caijuan

机构信息

Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, China.

Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, Haikou, China.

出版信息

Front Microbiol. 2024 Sep 19;15:1464135. doi: 10.3389/fmicb.2024.1464135. eCollection 2024.

DOI:10.3389/fmicb.2024.1464135
PMID:39364162
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11446753/
Abstract

Bacterial infections pose a significant clinical burden on global health. The growing incidence of drug-resistant pathogens highlights the critical necessity to identify and isolate bioactive compounds from marine resources. Marine-derived fungi could provide novel lead compounds against pathogenic bacteria. Due to the particularity of the marine environment, species derived from marine sources have proven to be potent producers of bioactive secondary metabolites and have played a considerable role in advancing drug development. This study reviews the structural diversity and activities against pathogenic bacteria of secondary metabolites isolated from marine-derived species over the past 14 years (January 2010-June 2024), and 337 natural products (including 145 new compounds) were described. The structures were divided into five major categories-terpenoids, nitrogen-containing compounds, polyketides, steroids, and other classes. These antimicrobial metabolites will offer lead compounds to the development and innovation of antimicrobial agents.

摘要

细菌感染给全球健康带来了重大的临床负担。耐药病原体发病率的不断上升凸显了从海洋资源中识别和分离生物活性化合物的迫切必要性。海洋来源的真菌可以提供对抗病原菌的新型先导化合物。由于海洋环境的特殊性，海洋来源的物种已被证明是生物活性次生代谢产物的有效生产者，并在推动药物开发方面发挥了重要作用。本研究综述了过去14年（2010年1月至2024年6月）从海洋来源物种中分离出的次生代谢产物的结构多样性及其对病原菌的活性，并描述了337种天然产物（包括145种新化合物）。这些结构分为五大类——萜类化合物、含氮化合物、聚酮化合物、甾体化合物和其他类别。这些抗菌代谢产物将为抗菌药物的开发和创新提供先导化合物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97df/11446753/b7131976b686/fmicb-15-1464135-g018.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97df/11446753/b8c879e6781f/fmicb-15-1464135-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97df/11446753/83cdaa6a261f/fmicb-15-1464135-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97df/11446753/ba08d72e695b/fmicb-15-1464135-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97df/11446753/6ddacc0e1f66/fmicb-15-1464135-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97df/11446753/526a59b72c13/fmicb-15-1464135-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97df/11446753/598b7037faee/fmicb-15-1464135-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97df/11446753/525f0dd4fd07/fmicb-15-1464135-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97df/11446753/0318f0eee14b/fmicb-15-1464135-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97df/11446753/3d4761d6853e/fmicb-15-1464135-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97df/11446753/5050917f1227/fmicb-15-1464135-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97df/11446753/d933e3afd02c/fmicb-15-1464135-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97df/11446753/4ecc72ee1aca/fmicb-15-1464135-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97df/11446753/929f6eb2a525/fmicb-15-1464135-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97df/11446753/f05173d2be6f/fmicb-15-1464135-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97df/11446753/9b4aedb28d64/fmicb-15-1464135-g015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97df/11446753/4ec10f68e5ab/fmicb-15-1464135-g016.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97df/11446753/365060cd7e4e/fmicb-15-1464135-g017.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97df/11446753/b7131976b686/fmicb-15-1464135-g018.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97df/11446753/b8c879e6781f/fmicb-15-1464135-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97df/11446753/83cdaa6a261f/fmicb-15-1464135-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97df/11446753/ba08d72e695b/fmicb-15-1464135-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97df/11446753/6ddacc0e1f66/fmicb-15-1464135-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97df/11446753/526a59b72c13/fmicb-15-1464135-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97df/11446753/598b7037faee/fmicb-15-1464135-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97df/11446753/525f0dd4fd07/fmicb-15-1464135-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97df/11446753/0318f0eee14b/fmicb-15-1464135-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97df/11446753/3d4761d6853e/fmicb-15-1464135-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97df/11446753/5050917f1227/fmicb-15-1464135-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97df/11446753/d933e3afd02c/fmicb-15-1464135-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97df/11446753/4ecc72ee1aca/fmicb-15-1464135-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97df/11446753/929f6eb2a525/fmicb-15-1464135-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97df/11446753/f05173d2be6f/fmicb-15-1464135-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97df/11446753/9b4aedb28d64/fmicb-15-1464135-g015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97df/11446753/4ec10f68e5ab/fmicb-15-1464135-g016.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97df/11446753/365060cd7e4e/fmicb-15-1464135-g017.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97df/11446753/b7131976b686/fmicb-15-1464135-g018.jpg

相似文献

1
Significance of research on natural products from marine-derived species as a source against pathogenic bacteria.对源自海洋物种的天然产物作为抗病原菌来源的研究意义。
Front Microbiol. 2024 Sep 19;15:1464135. doi: 10.3389/fmicb.2024.1464135. eCollection 2024.
2
Secondary Metabolites from Marine-Derived Fungi from China.来自中国海洋真菌的次生代谢产物
Prog Chem Org Nat Prod. 2020;111:81-153. doi: 10.1007/978-3-030-37865-3_2.
3
Marine : A Treasure Trove of Antimicrobial Compounds.海洋：抗菌化合物的宝库。
Mar Drugs. 2023 Apr 28;21(5):277. doi: 10.3390/md21050277.
4
Bioactive Secondary Metabolites from a Thai Collection of Soil and Marine-Derived Fungi of the Genera Neosartorya and Aspergillus.从泰国采集的新萨托菌属和曲霉属土壤及海洋来源真菌中提取的生物活性次生代谢产物。
Curr Drug Deliv. 2016;13(3):378-88. doi: 10.2174/1567201813666160303104641.
5
[New natural products from the marine-derived Aspergillus fungi-A review].[来自海洋来源曲霉属真菌的新型天然产物——综述]
Wei Sheng Wu Xue Bao. 2016 Mar 4;56(3):331-62.
6
Research Advances of Bioactive Sesquiterpenoids Isolated from Marine-Derived sp.海洋来源 sp. 中分离得到的生物活性倍半萜类化合物的研究进展
Molecules. 2022 Oct 30;27(21):7376. doi: 10.3390/molecules27217376.
7
Secondary Metabolites from Marine-Derived Bacteria with Antibiotic and Antibiofilm Activities against Drug-Resistant Pathogens.海洋来源细菌的次生代谢产物具有抗耐药病原菌的抗生素和抗生物膜活性。
Mar Drugs. 2023 Jan 12;21(1):50. doi: 10.3390/md21010050.
8
Natural products from marine fungi as a source against agricultural pathogenic fungi.海洋真菌来源的天然产物作为防治农业病原菌的物质。
Appl Microbiol Biotechnol. 2023 Aug;107(16):5003-5017. doi: 10.1007/s00253-023-12657-3. Epub 2023 Jul 4.
9
Recent Discovery of Nitrogen Heterocycles from Marine-Derived Species.海洋源物种中氮杂环的最新发现。
Mar Drugs. 2024 Jul 18;22(7):321. doi: 10.3390/md22070321.
10
Cytotoxic Compounds from Marine Fungi: Sources, Structures, and Bioactivity.海洋真菌中的细胞毒性化合物：来源、结构和生物活性。
Mar Drugs. 2024 Jan 28;22(2):70. doi: 10.3390/md22020070.

引用本文的文献

1
Biological Activities of Aspergillus niger MF6: Antimicrobial, Antioxidant, and Cytotoxic Potential of Marine-Derived Fungus Metabolites.黑曲霉MF6的生物活性：海洋来源真菌代谢产物的抗菌、抗氧化和细胞毒性潜力
Curr Microbiol. 2025 Aug 25;82(10):473. doi: 10.1007/s00284-025-04457-x.

本文引用的文献

1
Antimicrobial metabolites from the marine-derived fungus Aspergillus sp. ZZ1861.海洋来源真菌 Aspergillus sp. ZZ1861 的抗菌代谢产物。
Phytochemistry. 2024 Aug;224:114164. doi: 10.1016/j.phytochem.2024.114164. Epub 2024 May 24.
2
The scope of the antimicrobial resistance challenge.抗菌药物耐药性挑战的范围。
Lancet. 2024 Jun 1;403(10442):2426-2438. doi: 10.1016/S0140-6736(24)00876-6. Epub 2024 May 23.
3
Discovery of Antibacterial Compounds against subsp. from a Marine Fungus SCSIO 41202 and the Mode of Action.
从海洋真菌 SCSIO 41202 中发现抗 subsp. 的抗菌化合物及作用模式。
J Agric Food Chem. 2024 Jun 5;72(22):12596-12606. doi: 10.1021/acs.jafc.4c02769. Epub 2024 May 21.
4
Secondary metabolites from the deep-sea derived fungus MCCC M28183.源自深海真菌MCCC M28183的次生代谢产物。
Front Microbiol. 2024 Feb 14;15:1361550. doi: 10.3389/fmicb.2024.1361550. eCollection 2024.
5
Marine natural products.海洋天然产物。
Nat Prod Rep. 2024 Feb 21;41(2):162-207. doi: 10.1039/d3np00061c.
6
Nine New Antibacterial Diterpenes and Steroids from the South China Sea Soft Coral Tixier-Durivault.从中国南海软珊瑚蒂西耶 - 迪里沃（Tixier-Durivault）中分离出的九种新型抗菌二萜和甾体化合物 。
Mar Drugs. 2024 Jan 20;22(1):50. doi: 10.3390/md22010050.
7
Isolation and Structure Elucidation of New Metabolites from the Mariana-Trench-Associated Fungus sp. SY2601.从马里亚纳海沟相关真菌 sp. SY2601 中分离和结构阐明新代谢产物。
Molecules. 2024 Jan 17;29(2):459. doi: 10.3390/molecules29020459.
8
Discovery, Identification, and Mode of Action of Phenolics from Marine-Derived Fungus as Antibacterial Wilt Agents.从海洋来源真菌中发现、鉴定和作用模式的酚类化合物作为抗菌枯萎剂。
J Agric Food Chem. 2024 Feb 14;72(6):2989-2996. doi: 10.1021/acs.jafc.3c07826. Epub 2024 Jan 12.
9
Natural phenolic compounds: Antimicrobial properties, antimicrobial mechanisms, and potential utilization in the preservation of aquatic products.天然酚类化合物：抗菌特性、抗菌机制及其在水产品保鲜中的潜在应用。
Food Chem. 2024 May 15;440:138198. doi: 10.1016/j.foodchem.2023.138198. Epub 2023 Dec 15.
10
Antimicrobial Activity of Depsidones and Macrocyclic Peptides Isolated from Marine Sponge-Derived Fungus Aspergillus nidulans M256.海洋海绵来源真菌 Aspergillus nidulans M256 中分离得到的缩酚酸肽和大环肽的抗菌活性。
Chem Biodivers. 2023 Dec;20(12):e202301660. doi: 10.1002/cbdv.202301660. Epub 2023 Nov 22.