2nd Department of Psychiatry, University of Athens Medical School, Attikon General Hospital, 1 Rimini st Athens 12462, Greece.
BMC Psychiatry. 2010 Mar 2;10:19. doi: 10.1186/1471-244X-10-19.
Malformations of the cerebral cortex are often associated with developmental delay and psychoses. Porencephaly is a rare congenital disorder of central nervous system involving a cyst or a cavity filled with cerebrospinal fluid, in brain's parenchyma.
We present a 25 years old woman with her first psychotic episode. She also suffers from porencephaly in the frontotemporal lobes region. It is emphasized that the two consistently abnormal brain regions in schizophrenia research had significant damage in this patient since birth. There is a total of only five cases of schizencephaly or porencephaly associated with psychosis in the scientific literature. Their clinical characteristics as well as the imaging results are described.
It is unclear if porencephaly and psychosis concur by chance or are causally related. The area where the porencephalic cysts appear seems to be of relevance. This case highlights the need for further research.
大脑皮层的畸形通常与发育迟缓及精神疾病有关。脑裂畸形是一种罕见的中枢神经系统先天性疾病，其涉及脑实质中的充满脑脊液的囊或腔。
我们介绍了一位 25 岁的首次出现精神病性发作的女性患者，她还患有额颞叶区的脑裂畸形。值得强调的是，精神分裂症研究中两个一致的异常大脑区域在该患者出生时就已经存在明显损伤。在科学文献中仅有五例脑裂畸形或脑裂畸形伴发精神疾病的病例。描述了他们的临床特征和影像学结果。
目前尚不清楚脑裂畸形和精神疾病是偶然同时发生还是有因果关系。出现脑裂畸形的囊腔区域似乎与之相关。这个病例凸显了进一步研究的必要性。
