Raymond Nancy C, Grant Jon E, Coleman Eli
Department of Psychiatry, University of Minnesota Medical School, 2450 Riverside Avenue, Minneapolis, MN 55454, USA.
Ann Clin Psychiatry. 2010 Feb;22(1):56-62.
Compulsive sexual behavior (CSB) is generally characterized by recurrent and intense sexually arousing fantasies, sexual urges, and behaviors, which cause individuals distress or impair daily functioning. Descriptive studies of individuals with paraphilic and nonparaphilic CSB indicate that they experience urges to engage in problematic sexual behavior. The opiate antagonist naltrexone has been successfully used to treat a number of disorders in which urges to engage in problematic behavior are a central feature, such as alcoholism. We hypothesized that naltrexone would reduce the urges and behaviors associated with CSB.
Records of 19 male patients with CSB who were treated with naltrexone at an outpatient adult sexual health clinic were retrospectively reviewed.
Nearly all patients were already taking other psychotropic medications when naltrexone was initiated. Seventeen (89%) of the 19 patients reported a reduction in CSB symptoms when taking naltrexone for a period ranging from 2 months to 2.3 years, as judged by Clinical Global Impression scores of 1 or 2, indicating "very much improved" or "much improved." Five (26%) of the 19 patients chose to discontinue the medication.
Naltrexone may be a useful adjunctive treatment for CSB.
强迫性性行为（CSB）的一般特征是反复出现强烈的性唤起幻想、性冲动和行为，这些会给个体带来困扰或损害日常功能。对患有性偏好障碍和非性偏好障碍的CSB个体的描述性研究表明，他们会经历从事有问题性行为的冲动。阿片类拮抗剂纳曲酮已成功用于治疗一些以从事有问题行为的冲动为主要特征的疾病，如酒精中毒。我们假设纳曲酮会减少与CSB相关的冲动和行为。
回顾性分析了19名在成人门诊性健康诊所接受纳曲酮治疗的男性CSB患者的记录。
几乎所有患者在开始使用纳曲酮时都已在服用其他精神药物。根据临床总体印象评分为1或2（表明“非常改善”或“明显改善”）判断，19名患者中有17名（89%）报告在服用纳曲酮2个月至2.3年期间CSB症状有所减轻。19名患者中有5名（26%）选择停药。
纳曲酮可能是CSB的一种有用辅助治疗方法。
