Sultana Tania, Sahib Din Javeria
Psychopharmacology Research Program, The Manhattan Psychiatric Center, New York City, USA.
Psychiatry, Bergen New Bridge Medical Center, Paramus, USA.
Cureus. 2022 Jun 9;14(6):e25804. doi: 10.7759/cureus.25804. eCollection 2022 Jun.
Compulsive sexual behavior (CSB) or sexual addiction is a term that generally indicates excessive and uncontrolled sexual behavior. This may lead to subjective distress, social and occupational impairment, or legal and financial consequences. Often, this condition is underreported and untreated. Until now there are no FDA-approved medications for sexual addiction or compulsive sexual behaviors. However, the therapeutic benefits of selective serotonin reuptake inhibitors (SSRIs) and naltrexone are known. This is a case of a 53-year-old male with a history of extensive alcohol use, alcohol withdrawal seizure, and delirium tremens. The patient was treated with naltrexone 50 mg/day for alcohol use disorder. The patient reported that his "sexual compulsion" also reduced after the medication and there was an improvement in both alcohol addiction and self-reported compulsive sexual behavior. This case report also includes a literature review of pharmacotherapy, especially naltrexone, for the treatment of sexual addiction/compulsive sexual behavior. The literature review has shown that patients' symptoms were improved in different doses without side effects, and based on this and our experience, it can be said that naltrexone is effective in the reduction and remission of the symptoms of CSB or sexual addiction.
强迫性行为（CSB）或性成瘾是一个通常表示过度且不受控制的性行为的术语。这可能会导致主观痛苦、社会和职业功能受损，或产生法律和经济后果。通常，这种情况报告不足且未得到治疗。到目前为止，美国食品药品监督管理局（FDA）尚未批准用于治疗性成瘾或强迫性行为的药物。然而，选择性5-羟色胺再摄取抑制剂（SSRIs）和纳曲酮的治疗益处是已知的。这是一例53岁男性患者，有大量饮酒史、酒精戒断性癫痫发作和震颤谵妄病史。该患者因酒精使用障碍接受了每日50毫克纳曲酮的治疗。患者报告称，服药后他的“性冲动”也有所减轻，酒精成瘾和自我报告的强迫性行为均有改善。本病例报告还包括对药物治疗，尤其是纳曲酮治疗性成瘾/强迫性行为的文献综述。文献综述表明，不同剂量的纳曲酮均可改善患者症状且无副作用，基于此以及我们的经验，可以说纳曲酮在减轻和缓解CSB或性成瘾症状方面是有效的。
