Department of Psychiatry and Human Behavior, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma 371-8511, Japan.
Prog Neuropsychopharmacol Biol Psychiatry. 2010 May 30;34(4):624-31. doi: 10.1016/j.pnpbp.2010.02.025. Epub 2010 Mar 1.
Previous epidemiologic studies using the parental bonding instrument (PBI), a self-report scale to rate attitudes of parents during the first 16 years, have suggested that a lower parental care score or higher parental overprotection score could lead to an increased risk of several psychiatric disorders, including schizophrenia and mood disorder. However, neuroimaging studies of an association between PBI scores and brain developmental abnormalities are still limited. In this region-of-interest analysis study using a cross-sectional design, we examined 50 normal young adults, in terms of relationships of parental bonding styles during the first 16 years measured by PBI with regional gray matter (GM) volume in the dorsolateral prefrontal cortex (DLPFC). Our study showed that paternal care score positively correlated with the GM volume in the left DLPFC, and paternal and maternal overprotection score negatively correlated with the GM volume in the left DLPFC. In conclusion, our results suggest that in normal young adults, lower paternal care and higher parental overprotection scores correlated with the GM volume reduction in the DLPFC.
先前使用父母养育方式问卷（PBI）进行的流行病学研究，该问卷是一种自评量表，用于评估子女在 16 岁之前父母的态度，结果表明较低的亲职关怀评分或较高的父母过度保护评分可能会增加多种精神疾病的风险，包括精神分裂症和情绪障碍。然而，PBI 评分与大脑发育异常之间关联的神经影像学研究仍然有限。在这项使用横截面设计的基于感兴趣区的分析研究中，我们检查了 50 名正常年轻成年人，使用 PBI 测量他们在 16 岁之前的父母养育方式，探讨了与背外侧前额叶皮质（DLPFC）区域灰质（GM）体积的关系。我们的研究表明，父亲的关怀评分与左侧 DLPFC 的 GM 体积呈正相关，而父亲和母亲的过度保护评分与左侧 DLPFC 的 GM 体积呈负相关。总之，我们的结果表明，在正常年轻成年人中，较低的父亲关怀评分和较高的父母过度保护评分与 DLPFC 的 GM 体积减少相关。
