CAS Key Laboratory of Soft Matter Chemistry, Department of Polymer Science and Engineering, University of Science and Technology of China , Hefei, Anhui 230026, P. R. China.
ACS Appl Mater Interfaces. 2015 Feb 18;7(6):3618-25. doi: 10.1021/am507832n. Epub 2015 Feb 6.
A novel nanocontainer, which has silica nanotube (SNT) core and pH-sensitive polymer shell attaching on the exterior surface of silica nanotube, is presented in this paper. Polymer nanorods, which are conveniently fabricated though polymerization-induced self-assembly and reorganization method, are used as templates for the deposition of silica to fabricate hybrid nanorods. Calcination of as-synthesized silica hybrid nanorods leads to hollow SNTs. SNTs are functionalized with reversible addition-fragmentation chain transfer (RAFT) agent, then surface RAFT polymerization is conducted to get poly(2-(diethylamino)ethyl methacrylate)-b-poly(oligo(ethylene glycol) methacrylate)-coated SNTs (SNT-PDEAEMA-b-POEGMA). Doxorubicin (DOX) can be encapsulated in SNT-PDEAEMA-b-POEGMA, and controlled release of loaded DOX is achieved by adjusting pH of the medium. In vitro cell viability and cellular internalization study confirm the potential application of this nanocontainer in drug and gene delivery.
本文提出了一种新型纳米容器，它具有二氧化硅纳米管（SNT）内核和附着在二氧化硅纳米管外表面的 pH 敏感聚合物壳。聚合物纳米棒通过聚合诱导自组装和重组方法方便地制备，用作二氧化硅沉积的模板，以制备混合纳米棒。合成的二氧化硅杂化纳米棒经过煅烧得到中空的 SNTs。SNTs 用可逆加成-断裂链转移（RAFT）试剂进行功能化，然后进行表面 RAFT 聚合，得到聚（2-（二乙氨基）乙基甲基丙烯酸酯）-b-聚（聚乙二醇甲基丙烯酸酯）-包覆的 SNTs（SNT-PDEAEMA-b-POEGMA）。阿霉素（DOX）可以封装在 SNT-PDEAEMA-b-POEGMA 中，通过调节介质的 pH 值可以实现负载 DOX 的控制释放。体外细胞活力和细胞内化研究证实了这种纳米容器在药物和基因传递中的潜在应用。
